PMID: 25995342

Zhu Y, Liu C, Armstrong C, Lou W, Sandher A, Gao AC
Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer.
Clin Cancer Res. 2015 Sep 15;21(18):4133-42. doi: 10.1158/1078-0432.CCR-15-0269. Epub 2015 May 20., [PubMed]
Sentences
No. Mutations Sentence Comment
29 ABCB1 p.Ala595Gly
X
ABCB1 p.Ala595Gly 25995342:29:35
status: NEW
view ABCB1 p.Ala595Gly details
 b-Tubulin mutations, such as T26A, A595G, and F270I, have been demonstrated to impair tubulin polymerization in the presence of docetaxel in prostate cancer and breast cancer cell lines (13, 14). Login to comment