ABCC7 p.Ser670Ala
[switch to full view]Comments [show]
None has been submitted yet.
PMID: 15596536
[PubMed]
Csanady L et al: "Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain."
No.
Sentence
Comment
206
These results on gating of strongly phosphorylated CFTR channels in excised patches do not contradict the finding (Wilkinson et al., 1997) of a Յ2-fold reduction in sensitivity to activation by IBMX (hence presumably by PKA) of S660A or S670A CFTR channels in intact oocytes.
X
ABCC7 p.Ser670Ala 15596536:206:243
status: NEW
PMID: 9252549
[PubMed]
Wilkinson DJ et al: "CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain."
No.
Sentence
Comment
85
Activation constants for wild-type and single serine-to-alanine mutant CFTRs PICA Phosphorylation CFTR K4, n-m n Class In vivo In vitro Wild type 0.65 t 0.08 26 S64lA 0.6520.12 14 N No concensus S660A 1.21+ 0.19* 11 S ++ ++ S670A 0.99t0.12* 12 s ?
X
ABCC7 p.Ser670Ala 9252549:85:224
status: NEW
PMID: 23760269
[PubMed]
Billet A et al: "Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR)."
No.
Sentence
Comment
102
Carbachol Stimulates CFTR through PKA and Non-PKA Signaling Pathways-To explore PKA-independent regulation of CFTR without using inhibitors that might have confounding effects on other pathways, we studied the activation of 15SA-CFTR (S422A/S660A/S670A/S686A/T690A/S700A/S712A/ S737A/S753A/S768A/T787A/T788A/S790A/S795A/S813A).
X
ABCC7 p.Ser670Ala 23760269:102:247
status: NEW