ABCC1 p.Ala1227Lys
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PMID: 17257580
[PubMed]
Vincent M et al: "The predicted transmembrane fragment 17 of the human multidrug resistance protein 1 (MRP1) behaves as an interfacial helix in membrane mimics."
No.
Sentence
Comment
62
Peptides The peptide AGL-VGL-SVS-YSL-QVT-TYL-NWL-VRM-S (Mw=2797) (subsequently referred to as TM17), which encompasses the predicted transmembrane fragment 17 of MRP1, and its N-terminal mutant A1227K (called mTM17) (Mw=2853), were synthesized by Jerini (Berlin, Germany).
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ABCC1 p.Ala1227Lys 17257580:62:194
status: NEW
PMID: 20004175
[PubMed]
de Foresta B et al: "Interaction with membrane mimics of transmembrane fragments 16 and 17 from the human multidrug resistance ABC transporter 1 (hMRP1/ABCC1) and two of their tryptophan variants."
No.
Sentence
Comment
67
Similarly, a Ala1227Lys mutant of the TM17 fragment (mTM17) containing Trp1246 (or W20) [37] and the Tyr1236Trp and Trp1246Tyr variant of mTM17 (W10-mTM17), with its Trp closer to the extracellular side in the whole protein, were also synthesized (Table 1).
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ABCC1 p.Ala1227Lys 20004175:67:13
status: NEW
PMID: 24157718
[PubMed]
Abel S et al: "Bindings of hMRP1 transmembrane peptides with dodecylphosphocholine and dodecyl-beta-d-maltoside micelles: a molecular dynamics simulation study."
No.
Sentence
Comment
66
As for the TM17 peptide, we carried out MD simulations on two peptides: A first one (TM17) with the native sequence of the peptide and a second one (KTM17), where the first alanine residue was replaced by a lysine (i.e. A1227K).
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ABCC1 p.Ala1227Lys 24157718:66:220
status: NEW313 For the latter one, the A1227K mutation seems to promote the destabilization of the helical structure located above the mutation point at residue positions of L1231-S1236.
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ABCC1 p.Ala1227Lys 24157718:313:24
status: NEW