ABCMdb

PMID: 17257580

Vincent M, Gallay J, Jamin N, Garrigos M, de Foresta B
The predicted transmembrane fragment 17 of the human multidrug resistance protein 1 (MRP1) behaves as an interfacial helix in membrane mimics.
Biochim Biophys Acta. 2007 Mar;1768(3):538-52. Epub 2006 Dec 16., [PubMed]

Sentences

No. Mutations Sentence Comment

32 ABCC1 p.Trp1246Cys ABCC1 p.Trp1246Ala In particular, mutations in which Trp1246 was replaced by Cys, Ala, Phe, or Tyr abolished the transport of estradiol 17-(β-D-glucuronide), an endogenous estradiol metabolite formed in the liver and excreted into bile, and prevented the drug resistance mediated by MRP1 [10]. Login to comment 62 ABCC1 p.Ala1227Lys Peptides The peptide AGL-VGL-SVS-YSL-QVT-TYL-NWL-VRM-S (Mw=2797) (subsequently referred to as TM17), which encompasses the predicted transmembrane fragment 17 of MRP1, and its N-terminal mutant A1227K (called mTM17) (Mw=2853), were synthesized by Jerini (Berlin, Germany). Login to comment