Mutations at homologous positions to ABCA7 p.Arg524
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA7 |
p.Arg524Trp
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
ABCA1 |
p.Gly616Val
|
D
D
?
|
ABCA4 |
p.Glu627Ala
|
D
D
?
|
The alignment around the queried position:
ABCA7 485
D
G
P
A
A
D
P
L
T
D
L
R
Y
V
W
G
G
F
V
Y
L
Q
D
L
V
E
A
A
V
R
V
L
S
G
A
N
P
-
-
-
-
-
A
G
L
Y
L
Q
Q
M
P
Y
P
C
Y
V
D
D
V
F
L
R
V
L
S
R
S
L
P
L
F
L
T
L
A
W
I
559
ABCA1 575
P
G
P
A
D
P
F
E
D
M
Y
V
G
G
Y
L
D
V
V
E
Q
A
I
I
R
V
L
T
G
T
E
K
K
-
-
-
-
-
T
V
Y
M
Q
Q
M
P
Y
P
Y
V
D
D
I
F
L
R
V
S
S
P
L
F
M
T
L
A
W
I
649
ABCA2 644
R
P
G
P
N
T
G
-
-
G
R
F
Y
F
L
Y
G
-
F
V
W
I
Q
D
M
M
E
R
A
I
I
D
T
F
V
G
H
D
V
V
E
-
-
-
-
P
G
S
Y
V
Q
M
F
P
Y
P
C
Y
T
R
D
D
F
L
F
V
I
E
H
M
M
P
L
C
M
V
I
S
W
V
716
ABCA3 196
-
-
-
P
T
P
D
G
E
P
Y
I
E
F
A
V
H
A
V
D
R
A
I
M
E
Y
H
A
D
A
A
T
R
Q
L
F
Q
R
L
T
V
T
I
K
R
Y
P
F
I
A
P
F
L
V
A
I
Q
Y
Q
L
L
L
L
L
L
S
F
T
272
ABCA4 590
D
S
G
P
R
A
D
V
E
F
Y
A
Y
L
Q
D
M
Q
I
T
R
S
V
Q
A
A
P
-
-
-
-
-
V
G
I
Y
L
M
P
P
D
S
F
M
I
I
L
N
C
P
I
F
V
L
A
I
664
ABCA5 162
S
-
-
-
-
-
C
E
A
A
Q
Y
W
S
S
G
-
F
T
V
L
Q
A
S
I
D
A
A
I
I
Q
L
K
T
N
V
S
L
W
K
-
-
-
-
E
L
E
S
T
K
A
V
I
M
G
E
T
A
V
V
E
I
D
T
F
P
R
G
V
I
L
I
Y
L
V
I
A
F
S
P
231
ABCA6 159
G
Y
G
E
F
S
C
T
L
T
K
Y
W
N
R
G
-
F
V
A
L
Q
T
A
I
N
T
A
I
I
E
I
T
T
N
H
P
V
M
E
-
-
-
-
E
L
M
S
V
T
A
I
T
M
K
T
L
P
F
I
T
K
N
L
L
H
N
E
M
F
I
L
F
F
L
L
H
F
S
P
233
ABCA8 161
T
N
E
D
V
Y
C
E
V
S
V
F
W
K
E
G
-
F
V
A
L
Q
A
A
I
N
A
A
I
I
E
I
T
T
N
H
S
V
M
E
-
-
-
-
E
L
M
S
V
T
G
K
N
M
K
M
H
S
F
I
G
Q
S
G
V
I
T
D
L
Y
L
F
S
C
I
I
S
F
S
S
235
ABCA9 162
V
N
E
K
M
K
C
E
G
S
E
F
W
E
K
G
-
F
V
A
F
Q
A
A
I
N
A
A
I
I
E
I
A
T
N
H
S
V
M
E
-
-
-
-
Q
L
M
S
V
T
G
V
H
M
K
I
L
P
F
V
A
Q
G
G
V
A
T
D
F
F
I
F
F
C
I
I
S
F
S
T
236
ABCA10 72
M
H
G
E
I
F
C
Y
L
A
K
Y
W
L
K
G
-
F
V
A
F
Q
A
A
I
N
A
A
I
I
E
V
T
T
N
H
S
V
M
E
-
-
-
-
E
L
T
S
V
I
G
I
N
M
K
I
P
P
F
I
S
K
G
E
I
M
N
E
W
F
H
F
T
C
L
V
S
F
S
S
146
ABCA12 1004
A
P
G
P
H
N
S
P
S
H
N
Q
I
Y
G
R
A
-
F
I
Y
L
Q
D
S
I
E
R
A
I
I
E
L
Q
T
G
R
N
S
Q
E
-
-
-
-
I
A
V
Q
V
Q
A
I
P
Y
P
C
F
M
K
D
N
F
L
T
S
V
S
Y
S
L
P
I
V
L
M
V
A
W
V
1078
ABCA13 3507
K
F
H
P
Q
N
L
P
A
D
G
F
K
Y
N
Y
V
-
F
A
P
L
Q
D
M
I
E
R
A
I
I
L
V
Q
T
G
Q
E
A
L
E
-
-
-
-
P
A
A
Q
T
Q
A
A
P
Y
P
C
H
T
S
D
L
F
L
N
N
V
G
F
F
F
P
L
I
M
M
L
T
W
M
3581