Mutations at homologous positions to ABCC7 p.Cys592
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC7 |
p.Cys592Ser
p.Cys592Val
p.Cys592Leu
p.Cys592Thr
p.Cys592Ala
p.Cys592Phe
|
D
N
?
D
D
?
N
D
?
N
D
?
N
N
?
D
D
?
|
Mutations +/- 5 a.a. around the position:
| ABCC7 |
p.Phe587Ile
p.Glu588Val
p.Ser589Asn
p.Ser589Ile
p.Ser589Thr
p.Cys590*
p.Cys590Ser
p.Cys590Leu
p.Cys590Val
p.Cys590Phe
p.Cys590Thr
p.Cys590Ala
p.Cys590Trp
p.Lys593*
p.Met595Val
p.Met595Ile
|
N
D
?
D
D
N
N
N
D
N
N
-
-
?
D
D
?
D
D
?
D
N
?
D
D
?
D
D
?
D
D
?
D
D
?
-
-
?
D
N
?
N
N
?
|
| ABCC2 |
p.Gly808Thr
|
D
D
?
|
| ABCC3 |
p.Val799Met
|
N
N
?
|
| ABCC8 |
p.Lys880Ala
|
D
D
?
|
The alignment around the queried position:
1028ABCC7 553
S
L
V
V
L
A
N
T
K
M
K
K
I
L
Y
F
Y
F
S
E
632
ABCC1 775
R
V
S
L
A
R
A
Y
S
N
A
D
I
Y
L
F
L
S
A
V
D
A
H
V
G
K
H
I
F
E
N
V
I
G
P
K
G
M
L
K
N
K
T
R
I
L
V
T
S
M
S
Y
L
P
V
D
V
I
I
V
M
S
G
K
I
S
E
G
S
Y
Q
E
854
ABCC2 768
I
S
L
A
R
A
T
Y
Q
N
L
D
I
Y
L
L
D
P
L
A
V
A
H
V
G
K
H
I
F
K
V
L
G
P
N
L
L
K
G
K
T
R
L
L
V
T
H
S
M
H
F
L
P
Q
V
D
E
I
V
V
L
G
N
G
T
I
V
E
K
G
S
Y
S
A
847
ABCC3 758
R
V
S
L
A
R
A
Y
S
D
A
I
F
L
L
D
D
P
L
S
A
V
D
S
H
V
A
K
H
I
F
D
H
V
I
G
P
E
G
L
A
G
K
T
R
V
L
V
H
G
I
S
F
L
P
Q
T
D
F
I
I
V
L
A
D
G
Q
S
E
M
G
P
Y
P
A
837
ABCC4 542
R
V
N
L
A
R
V
Y
Q
D
A
D
I
L
D
D
P
L
S
A
V
D
A
E
V
S
R
H
L
F
L
C
I
C
Q
I
-
-
L
H
E
K
I
I
L
V
T
H
Q
L
Q
Y
L
K
A
S
Q
I
L
I
L
K
D
G
K
M
V
Q
K
G
T
Y
T
E
619
ABCC5 692
R
I
S
L
A
R
A
L
Y
S
D
R
S
I
Y
I
L
D
D
P
L
S
A
L
D
A
H
V
G
N
H
I
F
N
S
A
I
R
K
H
-
-
L
K
S
K
T
V
L
F
V
T
H
Q
L
Q
Y
L
V
D
C
D
E
V
I
F
M
K
E
G
C
I
T
E
R
G
T
H
E
E
769
ABCC6 760
L
S
L
A
V
K
A
A
V
Y
L
L
D
P
L
A
L
D
A
H
G
Q
H
V
F
Q
V
I
G
P
G
G
L
L
Q
G
T
T
I
L
H
A
L
H
I
L
P
Q
D
W
I
I
V
A
N
G
I
A
E
M
G
S
Y
Q
E
839
ABCC8 836
I
S
V
A
A
L
Y
Q
H
A
N
V
V
F
L
P
F
S
A
L
I
H
L
S
D
H
L
M
Q
A
G
I
L
E
L
L
R
D
D
R
T
V
V
L
V
T
L
Q
Y
L
P
H
A
D
I
I
A
M
K
D
G
I
Q
R
E
G
T
L
K
D
915
ABCC9 819
R
I
C
V
A
R
A
L
Y
Q
N
T
N
I
V
F
L
D
D
P
F
S
A
L
D
I
H
L
S
D
H
L
M
Q
E
G
I
L
K
F
L
Q
D
D
K
R
T
L
V
L
V
T
H
K
L
Q
Y
L
T
H
A
D
W
I
I
A
M
K
D
G
V
L
R
E
G
T
L
K
D
898
ABCC10 733
R
I
A
L
A
R
A
V
Y
Q
E
K
E
L
Y
L
L
D
D
P
L
A
A
V
D
A
D
V
A
N
H
L
L
H
R
C
I
L
G
M
L
S
Y
T
T
R
-
-
L
L
C
T
H
R
T
E
Y
L
E
R
A
D
A
V
L
L
M
E
A
G
R
L
I
R
A
G
P
P
S
E
810
ABCC11 641
R
I
S
L
A
R
A
V
Y
S
D
R
Q
I
Y
L
L
D
D
P
L
S
A
V
D
A
H
V
G
K
H
I
F
E
E
C
I
K
K
T
-
-
L
R
G
K
T
V
V
L
V
T
H
Q
L
Q
Y
L
E
F
C
G
Q
I
I
L
L
E
N
G
K
I
C
E
N
G
T
H
S
E
718
ABCC12 610
R
I
S
L
A
R
A
V
Y
S
D
R
Q
L
Y
L
L
D
D
P
L
S
A
V
D
A
H
V
G
K
H
V
F
E
E
C
I
K
K
T
-
-
L
R
G
K
T
V
V
L
V
T
H
Q
L
Q
F
L
E
S
C
D
E
V
I
L
L
E
D
G
E
I
C
E
K
G
T
H
K
E
687