Mutations at homologous positions to ABCA4 p.Leu1358
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA4 |
p.Leu1358Ala
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
ABCA4 |
p.Ala1357Thr
p.Ala1357Glu
p.Ala1357Val
|
N
D
?
N
D
?
N
D
?
|
ABCA1 |
p.Gln1328Arg
|
D
D
?
|
ABCA3 |
p.Lys914Arg
|
N
D
?
|
The alignment around the queried position:
ABCA4 1334
P
P
E
P
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
C
P
G
P
Q
L
N
T
G
T
Q
L
V
Q
H
V
Q
L
V
K
R
F
Q
H
T
I
S
H
K
D
F
L
A
Q
I
V
L
A
T
F
V
F
L
A
M
S
I
I
P
F
G
1398
ABCA1 1308
L
S
G
M
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
K
G
S
Y
Q
V
K
G
W
K
L
T
Q
Q
F
V
A
L
L
W
K
R
L
L
I
A
R
S
R
K
G
F
F
A
Q
I
V
L
P
A
V
F
V
I
A
L
V
F
S
L
I
V
P
P
F
G
1372
ABCA2 1403
P
Q
D
P
D
N
V
S
L
Q
E
V
E
A
E
A
L
S
R
V
G
Q
G
S
R
K
L
D
G
G
W
L
K
V
R
Q
F
H
G
L
L
V
K
R
F
H
C
A
R
R
N
S
K
A
L
F
S
Q
I
L
L
P
A
F
F
V
C
V
A
M
T
V
A
L
S
V
P
E
I
G
1482
ABCA3 892
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
R
T
A
V
K
L
N
T
G
L
A
L
H
C
Q
Q
F
W
A
M
F
L
K
A
A
Y
S
W
R
E
W
K
M
V
A
A
Q
V
L
V
L
T
C
V
T
L
A
L
A
I
Y
S
S
E
L
F
951
ABCA5 834
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
V
S
T
M
S
L
W
K
Q
Q
M
Y
T
I
A
K
F
H
F
F
T
L
K
R
E
S
K
S
V
R
S
V
L
L
L
L
L
I
F
F
T
V
Q
I
F
M
F
L
V
H
H
S
F
K
N
888
ABCA6 827
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
V
S
D
M
G
L
W
R
M
Q
V
F
A
M
A
R
L
R
F
L
K
L
K
R
Q
T
K
V
L
L
T
L
L
L
V
F
G
I
A
I
F
P
L
I
V
E
N
I
M
Y
A
M
L
N
E
881
ABCA7 1202
G
S
G
P
D
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
V
G
-
-
R
V
Q
G
W
A
L
T
R
Q
Q
L
Q
A
L
L
L
K
R
F
L
L
A
R
R
S
R
R
G
L
F
A
Q
I
V
L
P
A
L
F
V
G
L
A
L
V
F
S
L
I
V
P
P
F
G
1264
ABCA8 795
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
I
G
G
V
A
L
W
R
Q
Q
I
C
A
I
A
R
V
R
L
L
K
L
K
H
E
R
K
A
L
L
A
L
L
L
I
L
M
A
G
F
C
P
L
L
V
E
Y
T
M
V
K
I
Y
Q
N
849
ABCA9 836
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
I
S
G
V
A
L
W
R
Q
Q
V
C
A
I
A
K
V
R
F
L
K
L
K
K
E
R
K
S
L
W
T
I
L
L
L
F
G
I
S
F
I
P
Q
L
L
E
H
L
F
Y
E
S
Y
Q
K
890
ABCA10 746
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
V
S
S
A
A
L
W
R
R
Q
I
Y
A
V
A
T
L
R
F
L
K
L
R
R
E
R
R
A
L
L
C
L
L
L
V
L
G
I
A
F
I
P
I
I
L
E
K
I
M
Y
K
V
T
R
E
800
ABCA12 1718
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
R
L
D
G
F
G
L
L
L
K
K
I
M
A
I
L
I
K
R
F
H
H
T
R
R
N
K
G
L
I
A
Q
V
I
L
P
I
V
F
V
T
T
A
M
G
L
G
T
L
R
N
S
S
N
1772
ABCA13 4197
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
T
V
Q
G
V
Q
L
L
R
A
Q
V
A
A
I
L
A
R
R
L
R
R
T
L
R
A
G
K
S
T
L
A
D
L
L
L
P
V
L
F
V
A
L
A
M
G
L
F
M
V
R
P
L
A
T
4251