ABCA4 p.Leu1358Ala
| ClinVar: |
c.4073T>C
,
p.Leu1358Pro
?
, not provided
|
| Predicted by SNAP2: | A: D (53%), C: N (61%), D: D (71%), E: D (53%), F: N (61%), G: D (71%), H: N (53%), I: N (87%), K: D (59%), M: N (93%), N: D (59%), P: D (85%), Q: N (57%), R: D (63%), S: D (53%), T: N (61%), V: N (82%), W: D (66%), Y: N (61%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: N, K: D, M: N, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D, |
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[hide] Yeast ATP-Binding Cassette Transporters Conferring... Annu Rev Microbiol. 2012 Oct 13;66:39-63. Epub 2012 Jun 11. Prasad R, Goffeau A
Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance.
Annu Rev Microbiol. 2012 Oct 13;66:39-63. Epub 2012 Jun 11., [PMID:22703054]
Abstract [show]
Overexpression of the ATP-binding cassette (ABC) drug transporter P-glycoprotein (P-gp) is often responsible for the failure of chemotherapy as a treatment for human tumors. The presence of proteins homologous to P-gp in organisms ranging from prokaryotes to eukaryotes indicates that drug export is a general mechanism of multidrug resistance. Yeasts are no exception. They have developed a large subfamily of ABC exporters involved in pleiotropic drug resistance (PDR) and in the cellular efflux of a wide variety of drugs. The PDR transporters Pdr5p of Saccharomyces cerevisiae and Cdr1p of Candida albicans are important members of this PDR subfamily, which comprises up to 10 phylogenetic clusters in fungi. Here, we review current achievements concerning the structure, molecular mechanism, and physiological functions of yeast Pdr transporters.
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No. Sentence Comment
1152 52 Prasad ·Goffeau Pdr5p A676V Cdr1p Pdr5p T1213A Cdr1p Pdr5p C1294A E1289K C1294S E1289K/ Y1311S Cdr1p Pdr5p G1253A Cdr1p Pdr5p V773A V782I V773I V783I F774A F774Δ Cdr1p Pdr5p W683A C712A C732A S684A Cdr1p Pdr5p Y1311S L1352A L1353A F1354A T1355A M1356A C1357A L1358A N1359A F1360A C1361A G1362A V1363A L1364A A1365A G1366A Cdr1p Pdr5p A1346G S1360F A1347G S1360A N1348A S1360T L1349A A1350A T1364P T1351A T1364S T1364F Cdr1p C632A C635A Pdr5p S648P Pdr5p C1380A T1393I C1402A C1427Y C1418Y C1418A C1441A C1444A T1449I V1456I Cdr1p T1460I/ V1467I Cdr1p T658A A660G V662A L663A L664A A666G M667A V668A I669A Y670A G672A F673A V674A I675A P676A T677A P678A P659A T661A L665A T671A ECL5 TMS5 TMS7 TMS10 TMS8 TMS11 ECL3 TMS6 ECL6TMS9TMS4 TMS2 Cdr1p Pdr5p C1336A C1336S ND Cdr1p S558Y S558Y/ N242K Pdr5p ND ND NDND 12 C 1 2 53 64 87 119 10 N NBD2NBD1 Conservation HighLow Figure 5 A list of residues of Cdr1p and Pdr5p that have been subjected to mutational analyses.
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ABCA4 p.Leu1358Ala 22703054:1152:275
status: NEW