Mutations at homologous positions to ABCB11 p.Asp440
Alignment: ABCB_halves, Alignment of ABC subunits from proteins in the ABCB subfamily, 2011-11-21 18:43:41Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCB11 |
p.Asp440Glu
|
D
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCB11 |
p.Val444Ala
p.Val444Gly
p.Val444Asp
|
N
N
N
N
N
?
N
N
?
|
| ABCB1 |
p.Ile409Glu
p.Val417Ile
p.Ile1050Thr
p.Ile1050Cys
p.Pro1051Ala
p.Val1052Ile
|
D
D
?
N
N
?
N
D
?
N
D
?
D
D
?
N
N
?
|
The alignment around the queried position:
ABCB11 402
I
I
D
C
M
S
E
D
Y
K
D
-
I
K
G
E
E
F
N
V
T
F
H
Y
P
S
P
E
V
K
I
L
N
L
N
M
I
K
P
G
E
M
T
A
L
V
P
S
G
G
S
A
L
L
I
Q
F
D
P
C
E
G
M
V
T
480
ABCB1 374
S
I
D
S
Y
S
S
G
H
K
P
D
N
-
I
K
G
N
L
F
V
H
R
K
E
V
K
L
K
G
L
N
L
K
Q
S
G
Q
T
V
A
L
V
T
T
M
Q
R
D
P
T
V
452
ABCB1 1017
L
I
D
S
Y
S
T
E
G
L
M
N
T
-
E
G
N
V
F
G
E
V
V
F
T
R
P
D
L
Q
G
L
S
L
E
V
K
Q
L
A
L
V
V
V
L
L
E
P
L
A
K
V
-
1095
ABCB2 547
R
C
P
P
S
G
-
-
L
L
T
P
L
H
-
L
E
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
R
P
D
V
L
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
L
L
Q
N
L
Y
Q
P
T
G
G
Q
L
L
623
ABCB3 452
N
L
P
S
P
G
-
-
T
L
A
P
T
T
-
Q
G
V
V
K
F
Q
D
V
S
F
A
Y
P
N
R
P
D
R
P
V
L
K
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
G
G
Q
V
L
528
ABCB4 376
K
I
D
S
F
S
E
R
G
H
K
P
D
S
-
I
K
N
L
F
N
D
V
H
F
S
P
S
R
A
N
V
K
I
L
K
G
L
N
L
K
V
Q
S
G
Q
A
L
V
G
S
C
G
S
T
T
V
Q
L
I
Q
L
Y
D
P
D
G
T
I
N
454
ABCB4 1016
L
I
D
S
Y
S
E
E
L
K
P
D
K
-
F
E
G
N
I
T
F
N
E
V
V
F
Y
P
T
A
N
V
P
V
L
Q
G
L
S
L
E
V
K
K
G
Q
T
L
A
L
G
S
G
G
S
T
V
Q
L
E
R
F
Y
D
P
L
A
G
T
V
F
1094
ABCB5 552
N
I
D
S
R
S
Q
E
G
K
P
D
T
-
C
E
G
N
L
E
F
R
E
V
S
F
F
Y
C
R
P
V
F
I
L
R
G
L
S
L
S
I
E
R
G
K
T
V
A
F
V
G
S
S
G
C
G
K
S
T
S
V
Q
L
L
Q
R
L
Y
D
P
V
Q
G
Q
V
-
630
ABCB6 573
E
V
K
D
L
P
A
G
P
L
R
F
Q
-
-
K
R
I
E
F
E
N
V
H
F
S
Y
A
D
G
R
E
-
-
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
648
ABCB7 453
Q
I
K
D
K
V
M
A
S
P
L
Q
I
T
P
Q
T
A
T
V
A
F
D
N
V
H
F
E
Y
I
E
G
Q
K
-
-
V
L
S
G
I
S
F
E
V
P
A
G
K
K
V
A
I
V
G
G
S
G
S
G
K
S
T
I
V
R
L
L
F
R
F
Y
P
Q
K
G
S
I
Y
530
ABCB8 454
C
I
P
L
S
G
G
C
C
V
P
K
E
Q
-
L
R
G
S
V
T
F
Q
N
V
C
F
S
Y
P
C
R
P
G
F
E
V
L
K
D
F
T
L
T
L
P
P
G
K
I
V
A
L
V
G
Q
S
G
G
G
K
T
T
V
A
S
L
L
E
R
F
Y
D
P
T
A
G
V
V
M
532
ABCB9 488
T
M
V
H
D
G
-
-
S
L
A
P
D
H
-
L
E
G
R
V
D
F
E
N
V
T
F
T
Y
R
T
R
P
H
T
Q
V
L
Q
N
V
S
F
S
L
S
P
G
K
V
T
A
L
V
G
P
S
G
S
G
S
S
C
V
N
I
L
E
N
F
Y
P
L
E
G
G
R
V
L
564
ABCB10 474
K
L
P
F
N
E
G
V
I
L
N
E
K
S
-
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
P
A
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
552
ABCB11 1060
P
I
S
V
Y
N
T
A
G
E
K
W
D
N
-
F
Q
G
K
D
F
V
D
K
F
T
Y
P
S
P
D
S
Q
V
L
N
G
L
S
V
S
I
S
P
G
Q
T
L
F
G
S
C
G
K
T
S
I
Q
L
L
E
F
Y
P
D
Q
G
K
V
-
1138