Mutations at homologous positions to ABCC2 p.Thr1477
Alignment: ABCC_full, Alignment of full length ABCC proteins, 2016-02-18 11:19:27Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCC2 |
p.Thr1477Met
|
N
N
?
|
| ABCC8 |
p.Lys1521Asn
|
N
N
?
|
Mutations +/- 5 a.a. around the position:
| ABCC4 |
p.Arg1220Gln
|
N
D
?
|
| ABCC7 |
p.Tyr1381His
p.Tyr1381*
p.Gln1382Arg
p.Gln1382*
p.Ile1383*
p.Leu1388Val
p.Leu1388Gln
p.Gln1390*
p.Gln1390Ala
|
N
N
-
-
N
N
?
-
-
-
-
?
N
N
?
D
D
-
-
N
N
?
|
| ABCC8 |
p.Val1523Leu
p.Val1523Ala
p.Val1523Met
|
D
N
D
N
D
D
N
D
D
|
The alignment around the queried position:
1829ABCC2 1438
S
I
G
Q
R
Q
L
L
L
G
R
L
L
R
K
S
K
I
L
V
L
D
E
A
T
A
A
V
D
L
E
T
D
N
L
I
Q
T
I
Q
N
E
F
A
H
C
T
V
I
T
I
H
R
L
H
T
I
M
D
S
D
K
V
M
V
L
D
N
G
K
I
I
E
G
S
1517
ABCC1 1431
S
Q
Q
V
L
A
R
A
L
L
R
K
T
K
I
L
V
L
A
T
A
V
D
L
E
T
D
D
L
I
Q
S
T
I
R
T
Q
F
E
D
T
V
L
T
I
A
R
N
T
D
Y
T
R
K
E
Q
Y
A
1510
ABCC3 1427
S
V
G
Q
R
Q
L
V
C
L
A
R
A
L
L
R
K
S
R
I
L
V
L
D
E
A
T
A
A
I
D
L
E
T
D
N
L
I
Q
A
T
I
R
T
Q
F
D
T
C
V
L
T
I
A
H
R
L
N
T
I
M
D
Y
T
V
L
V
L
D
K
G
V
V
A
E
F
D
S
1506
ABCC4 1178
S
V
G
Q
R
Q
L
V
C
L
A
R
A
I
L
R
K
N
Q
I
L
I
I
D
A
T
A
N
V
D
P
R
T
D
E
L
I
Q
K
K
I
E
K
F
A
H
C
T
V
L
T
I
A
H
R
L
N
T
I
I
D
S
D
K
I
M
V
L
D
S
G
R
L
K
E
Y
D
E
1257
ABCC5 1331
S
V
G
E
R
Q
L
L
C
I
A
R
A
L
L
R
H
C
K
I
L
I
L
D
E
A
T
A
A
M
D
T
E
T
D
L
L
I
Q
E
T
I
R
E
A
F
A
D
C
T
M
L
I
A
H
R
L
H
T
V
L
S
D
R
I
M
V
L
A
Q
G
Q
V
V
E
F
D
T
1410
ABCC6 1403
V
K
Q
L
L
C
L
A
R
A
L
K
T
Q
I
L
L
D
A
T
A
A
V
D
P
G
T
E
L
Q
M
Q
A
M
L
G
S
W
F
A
Q
C
T
V
L
L
I
A
H
L
S
V
M
D
C
A
R
V
L
V
M
D
K
G
Q
V
A
E
S
S
1482
ABCC7 1347
M
L
A
S
V
L
S
K
K
L
L
S
L
P
I
R
R
T
K
A
A
I
A
L
V
Q
1426
ABCC8 1482
Q
R
Q
L
F
C
L
A
A
F
V
R
K
T
I
F
I
M
A
T
A
S
I
M
A
E
N
I
L
Q
V
M
T
A
F
A
D
V
V
T
I
A
R
V
H
I
S
A
D
L
V
I
K
R
G
I
L
E
F
D
K
1561
ABCC9 1450
S
V
G
Q
R
Q
L
F
C
L
A
R
F
V
R
K
S
S
I
L
I
M
D
E
A
T
A
S
I
D
M
A
T
E
N
I
L
Q
K
V
V
M
T
A
F
A
D
R
T
V
V
T
I
A
H
R
V
S
S
I
M
D
G
L
V
L
V
F
S
E
G
I
V
E
C
D
T
1529
ABCC10 1383
S
L
Q
R
Q
L
L
C
L
A
R
A
L
L
T
D
A
K
I
L
C
I
D
E
A
T
A
S
V
D
Q
K
T
D
Q
L
L
Q
Q
T
I
C
K
R
F
A
N
K
T
V
L
T
I
A
H
R
L
N
T
I
L
N
S
D
R
V
L
V
L
Q
A
G
R
V
V
E
L
D
S
1462
ABCC11 1279
S
V
G
E
R
Q
L
L
C
I
A
R
A
V
L
R
N
S
K
I
I
L
I
D
E
A
T
A
S
I
D
M
E
T
D
T
L
I
Q
R
T
I
R
E
A
F
Q
G
C
T
V
L
V
I
A
H
R
V
T
T
V
L
N
C
D
H
I
L
V
M
G
N
G
K
V
V
E
F
D
R
1358
ABCC12 1258
S
V
G
E
R
Q
L
L
C
V
A
R
A
L
L
R
N
S
K
I
I
L
L
D
E
A
T
A
S
M
D
S
K
D
T
L
V
Q
N
T
I
K
D
A
F
K
G
C
T
V
L
T
I
A
H
R
L
N
T
V
L
N
C
D
H
V
L
V
M
E
N
G
K
V
I
E
F
D
K
1337