Mutations at homologous positions to ABCA7 p.Asn718
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA7 |
p.Asn718Thr
|
N
D
?
|
Mutations +/- 5 a.a. around the position:
ABCA12 |
p.Trp1235Ser
|
D
D
?
|
ABCA4 |
p.Gly818Glu
p.Trp821Arg
p.Ile824Thr
|
D
D
D
D
D
D
?
|
The alignment around the queried position:
ABCA7 679
D
R
L
P
A
G
G
R
V
A
A
S
L
L
S
P
V
A
F
G
F
G
C
E
S
L
A
L
L
E
E
Q
G
E
G
A
Q
W
H
V
G
T
R
P
T
-
A
D
V
F
S
L
A
Q
V
S
G
L
L
L
L
D
A
A
L
Y
G
L
A
T
W
Y
L
E
A
V
C
P
G
757
ABCA1 769
D
Y
G
F
L
I
F
A
S
L
L
S
P
V
A
F
F
G
E
F
A
L
F
E
E
Q
G
I
G
V
Q
W
D
N
L
F
E
S
P
V
E
D
G
F
N
L
T
T
S
M
M
L
F
T
F
L
Y
G
V
M
T
Y
I
E
A
V
F
P
G
848
ABCA2 840
D
K
I
T
A
F
E
K
C
I
A
S
L
M
S
T
T
A
F
G
L
G
S
K
Y
F
A
L
Y
E
V
A
G
V
G
I
Q
W
H
T
F
S
Q
S
P
V
E
G
D
D
F
N
L
L
L
A
V
T
M
L
M
V
D
A
V
V
Y
G
I
L
T
W
Y
I
E
A
V
H
P
G
919
ABCA3 397
N
W
M
T
L
S
Q
K
L
C
S
C
L
L
S
N
V
A
M
A
M
G
A
Q
L
I
G
K
F
E
A
K
G
M
G
I
Q
W
R
D
L
L
S
P
V
N
V
D
D
D
F
C
F
G
Q
V
L
G
M
L
L
L
D
S
V
Y
G
L
V
T
W
Y
M
E
A
V
F
P
G
476
ABCA4 784
D
R
M
T
A
E
L
K
K
A
V
L
S
P
V
F
G
F
G
T
E
L
V
R
F
E
E
Q
G
L
L
Q
S
N
G
N
S
P
T
E
G
D
E
F
S
F
L
S
Q
M
M
L
L
A
L
L
L
D
Q
V
F
863
ABCA5 350
S
F
P
K
S
L
V
W
L
F
S
P
F
C
H
C
T
F
V
I
G
I
A
Q
V
M
H
L
E
D
F
N
E
G
A
S
F
S
N
L
T
-
-
-
-
-
A
G
P
Y
P
L
I
I
T
I
I
M
L
T
L
N
S
I
F
Y
V
L
L
A
V
Y
L
D
Q
V
I
P
G
E
424
ABCA6 350
Q
L
P
S
S
L
E
W
I
L
N
I
C
S
P
F
A
F
T
T
G
M
I
Q
I
I
K
L
D
Y
N
L
N
G
V
I
F
P
D
P
S
-
-
-
-
-
G
D
S
Y
T
M
I
A
T
F
S
M
L
L
L
D
G
L
I
Y
L
L
L
A
L
Y
F
D
K
I
L
P
Y
G
424
ABCA8 352
H
L
P
A
S
L
E
W
I
L
S
L
L
S
P
F
A
F
M
L
G
M
A
Q
L
L
H
L
D
Y
D
L
N
S
N
A
F
P
H
P
S
-
-
-
-
-
D
G
S
N
L
I
V
A
T
N
F
M
L
A
F
D
T
C
L
Y
L
A
L
A
I
Y
F
E
K
I
L
P
N
E
426
ABCA9 353
R
L
P
A
F
L
E
W
T
L
C
L
L
S
P
F
A
F
T
V
G
M
A
Q
L
I
H
L
D
Y
D
V
N
S
N
A
H
L
D
S
S
-
-
-
-
-
Q
N
P
Y
L
I
I
A
T
L
F
M
L
V
F
D
T
L
L
Y
L
V
L
T
L
Y
F
D
K
I
L
P
A
E
427
ABCA10 263
Q
L
L
S
L
G
W
V
L
S
L
L
S
P
F
A
F
T
A
G
M
A
Q
I
T
H
L
D
N
Y
L
S
G
V
I
F
P
D
P
S
-
-
-
-
-
G
D
S
Y
K
M
I
A
T
F
F
I
L
A
F
D
T
L
F
Y
L
I
F
T
L
Y
F
E
R
V
L
P
D
K
337
ABCA12 1198
N
E
L
S
Y
V
L
K
V
F
M
S
L
L
S
P
T
A
F
S
Y
A
S
Q
Y
I
A
Y
E
E
Q
G
I
G
L
Q
E
N
M
Y
T
S
P
V
Q
D
D
T
T
S
F
G
W
L
C
C
L
I
L
A
D
S
F
I
Y
F
L
I
A
W
Y
V
R
N
V
F
P
G
1277
ABCA13 3701
N
Q
L
F
V
N
Q
T
F
L
C
L
L
S
T
T
A
F
G
Q
G
V
F
F
I
T
F
L
E
G
Q
E
T
G
I
Q
W
N
N
M
Y
Q
A
L
E
Q
G
G
M
T
-
F
G
W
V
C
W
M
I
L
F
D
S
S
L
Y
F
L
C
G
W
Y
L
S
N
L
I
P
G
3779