Mutations at homologous positions to ABCA4 p.Ala1637
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
|
SNAP2 PROVEAN Effect_dbs |
||
|---|---|---|
| ABCA4 |
p.Ala1637Thr
|
D
D
|
Mutations +/- 5 a.a. around the position:
| ABCA4 |
p.Arg1640Trp
p.Arg1640Gln
p.Ser1642Arg
|
D
D
D
D
N
N
|
| ABCA1 |
p.Asn1611Asp
p.Arg1615Pro
p.Arg1615Gln
p.Arg1615Trp
|
D
D
?
D
D
?
D
D
?
D
D
?
|
| ABCA7 |
p.Arg1489Gln
p.Arg1496Pro
|
D
N
?
D
D
?
|
The alignment around the queried position:
ABCA4 1602
I
P
D
-
-
-
-
F
L
K
H
L
E
T
E
N
K
W
F
N
N
K
H
A
L
V
S
F
N
V
A
H
N
I
L
A
L
P
K
D
R
-
S
P
E
E
G
I
T
V
I
S
Q
P
N
L
K
E
Q
L
S
E
I
T
V
L
T
1676
ABCA1 1577
L
G
R
-
-
-
-
F
M
T
G
L
D
T
N
N
V
K
V
W
F
N
N
K
G
W
A
I
S
S
F
L
N
V
I
N
A
I
L
A
N
L
Q
K
G
E
-
N
P
S
H
Y
G
I
T
A
F
N
H
P
L
N
L
T
K
Q
Q
L
S
E
V
A
M
T
T
1651
ABCA2 1710
F
G
T
R
A
P
P
M
V
R
K
I
A
V
R
R
A
A
Q
V
F
Y
N
N
K
G
Y
H
S
M
P
T
Y
L
N
S
L
N
N
A
I
L
R
A
N
L
P
K
S
K
G
N
P
A
A
Y
G
I
T
V
T
N
H
P
M
N
K
T
S
A
S
L
S
L
D
Y
L
L
Q
G
1789
ABCA3 1029
-
-
-
-
-
-
-
-
F
R
D
V
G
E
R
T
V
V
N
A
L
F
N
N
Q
A
Y
H
S
P
A
T
A
L
A
V
V
D
N
L
L
F
K
L
L
C
G
P
H
-
-
-
-
-
-
S
I
V
V
S
F
P
Q
P
S
A
L
Q
A
K
D
Q
F
N
E
G
1094
ABCA5 963
-
-
-
-
-
-
-
-
-
-
-
E
K
D
Y
V
F
A
A
V
F
N
S
T
M
V
Y
S
L
P
I
L
V
N
I
I
S
N
Y
Y
L
Y
H
L
N
V
T
E
T
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
I
W
S
T
P
F
F
Q
E
I
T
D
I
V
F
K
I
1019
ABCA6 957
-
-
-
-
-
-
-
-
-
-
-
Q
K
D
Y
R
F
S
V
V
C
N
T
K
R
L
H
C
F
P
I
L
M
N
I
I
S
N
G
L
L
Q
M
F
N
H
T
Q
H
-
-
-
-
-
-
-
-
-
-
-
-
I
R
I
E
S
S
P
F
P
L
S
-
-
H
I
G
L
W
T
1011
ABCA7 1458
L
T
A
-
-
-
-
W
A
H
S
L
D
A
Q
D
S
L
K
I
W
F
N
N
K
G
W
H
S
M
V
A
F
N
A
S
N
A
I
L
A
H
L
P
P
G
P
-
A
R
A
H
S
I
T
T
L
N
H
P
L
N
L
T
K
E
Q
L
S
E
A
L
M
A
S
1532
ABCA8 925
-
-
-
-
-
-
-
-
-
-
-
E
K
N
Y
S
F
S
L
A
C
N
A
K
R
L
N
C
F
P
V
L
M
D
I
V
S
N
G
L
L
G
M
V
K
P
S
V
H
-
-
-
-
-
-
-
-
-
-
-
-
I
R
T
E
R
S
T
F
L
E
N
-
-
G
Q
D
N
P
I
979
ABCA9 966
-
-
-
-
-
-
-
-
-
-
-
E
K
D
H
R
F
S
I
A
C
N
T
K
R
L
N
C
F
P
V
L
L
D
V
I
S
N
G
L
L
G
I
F
N
S
S
E
H
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
T
D
R
S
T
F
F
E
E
-
-
H
M
D
Y
E
Y
1020
ABCA10 876
-
-
-
-
-
-
-
-
-
-
-
Q
K
D
Y
R
F
S
V
A
C
N
T
K
K
L
N
C
F
P
V
L
M
G
I
V
S
N
A
L
M
G
I
F
N
F
T
E
L
-
-
-
-
-
-
-
-
-
-
-
-
I
Q
M
E
S
T
S
F
S
R
D
-
-
D
I
V
L
D
L
930
ABCA12 1918
-
-
-
-
-
-
-
-
-
-
V
P
A
N
R
T
L
A
K
V
W
Y
D
P
E
G
Y
H
S
L
P
A
Y
L
N
S
L
N
N
F
L
L
R
V
N
M
S
-
K
Y
D
A
A
R
-
H
G
I
I
M
Y
S
H
P
Y
P
-
-
G
V
Q
D
Q
E
Q
A
I
S
S
1983
ABCA13 4386
-
-
-
-
-
-
-
-
-
-
I
S
K
P
P
T
L
A
K
V
W
Y
N
Q
K
G
F
H
S
L
P
S
Y
L
N
H
L
N
N
L
I
L
W
Q
H
L
P
P
T
V
D
W
R
Q
-
Y
G
I
T
L
Y
S
H
P
Y
G
-
-
G
A
L
L
N
K
D
K
I
L
E
S
4452