Mutations at homologous positions to ABCA4 p.Thr959
Alignment: ABCA_full, Alignment of full length ABCA proteins, 2016-02-18 11:17:15Mutations exactly at the same position:
SNAP2 PROVEAN Effect_dbs |
||
---|---|---|
ABCA4 |
p.Thr959Ile
p.Thr959Ala
|
D
D
N
D
?
|
ABCA1 |
p.Thr929Ile
|
D
D
?
|
Mutations +/- 5 a.a. around the position:
ABCA4 |
p.Tyr954Ser
p.Tyr954Asp
p.Glu955Gly
p.Gly963Ala
|
D
D
?
D
D
D
D
?
D
D
?
|
ABCA1 |
p.Tyr924Phe
p.Ser930Phe
|
D
D
?
D
D
?
|
ABCA3 |
p.Ile561Phe
|
N
D
?
|
The alignment around the queried position:
ABCA4 922
H
P
G
W
V
P
G
V
C
K
N
L
K
I
E
C
G
-
-
P
A
V
D
R
L
N
I
T
F
N
Q
I
A
F
L
H
A
G
L
I
L
L
L
S
G
T
V
L
G
R
-
-
D
I
E
T
S
997
ABCA1 892
P
T
H
L
K
L
G
V
S
I
Q
N
L
V
K
V
Y
D
G
M
K
-
-
V
A
V
G
L
A
L
N
F
E
G
Q
I
F
L
G
H
G
G
T
T
M
S
I
L
T
L
F
P
P
T
S
G
T
A
I
L
G
K
-
-
D
I
S
E
967
ABCA2 983
P
T
H
L
P
L
V
V
C
V
D
K
L
T
K
V
Y
K
D
D
K
K
-
-
L
A
L
N
K
L
S
L
N
L
Y
E
N
Q
V
V
S
F
L
G
H
N
G
A
G
K
T
T
T
M
S
I
L
T
G
L
F
P
P
T
S
G
S
A
T
I
Y
G
H
-
-
D
I
R
T
E
1058
ABCA3 523
P
E
D
L
V
A
G
I
K
I
K
H
L
S
K
V
F
R
V
G
N
K
D
R
A
A
V
R
D
L
N
L
L
Y
E
G
Q
T
V
L
L
G
H
G
K
T
T
L
S
M
T
G
L
F
P
T
S
G
R
A
Y
I
S
Y
-
-
E
I
S
Q
D
600
ABCA5 472
F
V
G
K
E
A
I
R
I
S
G
I
Q
K
T
Y
R
K
K
G
E
N
V
E
A
L
R
N
L
S
F
D
I
Y
E
G
Q
I
T
A
L
L
G
H
S
G
T
G
K
S
T
L
M
N
I
L
C
G
L
C
P
P
S
D
G
F
A
S
I
Y
G
H
R
V
S
E
I
D
E
M
551
ABCA6 472
F
Q
G
K
E
A
I
R
I
R
N
V
K
K
E
Y
K
G
K
S
G
K
V
E
A
L
K
G
L
L
F
D
I
Y
E
G
Q
I
T
A
I
L
G
H
S
G
A
G
K
S
S
L
L
N
I
L
N
G
L
S
V
P
T
E
G
S
V
T
I
Y
N
K
N
L
S
E
M
Q
D
L
551
ABCA7 800
P
P
G
L
S
P
G
V
S
V
R
S
L
E
K
R
F
P
G
S
P
Q
-
-
P
A
L
R
G
L
S
L
D
F
Y
Q
G
H
I
T
A
F
L
G
H
N
G
G
T
T
T
L
S
I
L
S
G
L
F
P
P
S
G
G
S
A
F
I
L
G
H
-
-
D
V
R
S
S
875
ABCA8 474
F
Q
G
K
E
A
I
R
I
R
N
V
T
K
E
Y
K
G
K
P
D
K
I
E
A
L
K
D
L
V
F
D
I
Y
E
G
Q
I
T
A
I
L
G
H
S
G
A
G
K
S
T
L
L
N
I
L
S
G
L
S
V
P
T
K
G
S
V
T
I
Y
N
N
K
L
S
E
M
A
D
L
553
ABCA9 475
F
C
G
K
E
A
I
R
I
K
N
L
K
K
E
Y
A
G
K
C
E
R
V
E
A
L
K
G
V
V
F
D
I
Y
E
G
Q
I
T
A
L
L
G
H
S
G
A
G
K
T
T
L
L
N
I
L
S
G
L
S
V
P
T
S
G
S
V
T
V
Y
N
H
T
L
S
R
M
A
D
I
554
ABCA10 385
F
H
G
K
E
A
I
R
I
R
N
V
I
K
E
Y
N
G
K
T
G
K
V
E
A
L
Q
G
I
F
F
D
I
Y
E
G
Q
I
T
A
I
L
G
H
N
G
A
G
K
S
T
L
L
N
I
L
S
G
L
S
V
S
T
E
G
S
A
T
I
Y
N
T
Q
L
S
E
I
T
D
M
464
ABCA12 1339
P
K
D
L
T
V
G
V
A
L
H
G
V
T
K
I
Y
G
-
-
-
-
S
K
V
A
V
D
N
L
N
L
N
F
Y
E
G
H
I
T
S
L
L
G
P
A
G
K
T
T
T
I
S
M
L
T
G
L
F
G
A
S
A
G
T
I
F
V
Y
G
K
-
-
D
I
K
T
D
1412
ABCA13 3835
L
E
G
S
A
P
G
V
T
L
V
S
V
T
K
E
Y
E
G
-
-
-
H
K
A
V
V
Q
D
L
S
L
T
F
Y
R
D
Q
I
T
A
L
L
G
T
N
G
A
G
K
T
T
I
I
S
M
L
T
G
L
H
P
P
T
S
G
T
I
I
I
N
G
K
-
-
N
L
Q
T
D
3909