ABCMdb

PMID: 9765504

Shoshani T, Zhang S, Dey S, Pastan I, Gottesman MM
Analysis of random recombination between human MDR1 and mouse mdr1a cDNA in a pHaMDR-dihydrofolate reductase bicistronic expression system.
Mol Pharmacol. 1998 Oct;54(4):623-30., [PubMed]

Sentences

No. Mutations Sentence Comment

111 ABCB1 p.Gly324Lys ABCB1 p.Ile299Met ABCB1 p.Ser351Asn ABCB1 p.Thr319Ser ABCB1 p.Leu322Ile Of the amino acid residues in TM domains 5 and 6 of this clone, 70% were from mouse mdr1a and 30% were from human MDR1, which resulted in five amino acid changes in MDR1: Ile299Met, Thr319Ser, Leu322Ile, Gly324Lys, and Ser351Asn. Login to comment 158 ABCB1 p.Gly324Lys The major change among the five amino acid changes in MDR1 is Gly324Lys [(i.e., Fig. 8. Login to comment 168 ABCB1 p.Gly185Val It has been previously shown that inhibitors of MDR1 show differential effects on reversing resistance of different drugs depending on whether the Pgp mutant G185V or wild-type transporters are analyzed (Cardarelli et al., 1995). Login to comment