PMID: 9508803

Lansdell KA, Delaney SJ, Lunn DP, Thomson SA, Sheppard DN, Wainwright BJ
Comparison of the gating behaviour of human and murine cystic fibrosis transmembrane conductance regulator Cl- channels expressed in mammalian cells.
J Physiol. 1998 Apr 15;508 ( Pt 2):379-92., 1998-04-15 [PubMed]
Sentences
No. Mutations Sentence Comment
218 ABCC7 p.Ser945Leu
X
ABCC7 p.Ser945Leu 9508803:218:206
status: NEW
view ABCC7 p.Ser945Leu details
ABCC7 p.Gly970Arg
X
ABCC7 p.Gly970Arg 9508803:218:216
status: NEW
view ABCC7 p.Gly970Arg details
 Consistent with this latter possibility, deletion of nineteen residues from the second intracellular loop (ICL2) promoted transitions to a subconductance state, while the I-V relationships of the mutations S945L and G970R located in ICL3 showed weak outward rectification in contrast to that of wild-type CFTR (Xie, Drumm, Ma & Davis, 1995; Seibert, Linsdell, Loo, Hanrahan, Riordan & Clarke, 1996b). Login to comment 239 ABCC7 p.Gly1069Arg
X
ABCC7 p.Gly1069Arg 9508803:239:29
status: NEW
view ABCC7 p.Gly1069Arg details
 When expressed in CHO cells, G1069R had a Pï intermediate between that of human and murine CFTR (Seibert, Linsdell, Loo, Hanrahan, Clarke & Riordan, 1996a; this study). Login to comment