PMID: 8830258

Paddon C, Loayza D, Vangelista L, Solari R, Michaelis S
Analysis of the localization of STE6/CFTR chimeras in a Saccharomyces cerevisiae model for the cystic fibrosis defect CFTR delta F508.
Mol Microbiol. 1996 Mar;19(5):1007-17., [PubMed]
Sentences
No. Mutations Sentence Comment
166 ABCC7 p.Arg553Gln
X
ABCC7 p.Arg553Gln 8830258:166:38
status: NEW
view ABCC7 p.Arg553Gln details
 These revertant mutations (R553 M and R553Q) lie in the CFTR-portion of NBD1 in the chimeric molecule. Login to comment 183 ABCC7 p.Arg553Gln
X
ABCC7 p.Arg553Gln 8830258:183:133
status: NEW
view ABCC7 p.Arg553Gln details
 Teem et al. (1993) speculated that loss of F508 may alter the structure of NBD1 in a manner that is partially compensated for by the R553Q or R553 M suppressor mutations which they isolated. Login to comment