ABCMdb

PMID: 8825488

Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I
Genetic analysis of the multidrug transporter.
Annu Rev Genet. 1995;29:607-49., [PubMed]

Sentences

No. Mutations Sentence Comment

163 ABCB1 p.Val338Ala A Val-to-Ala mutation at position 338 resulted in increased resistance to colchicine and doxorubicin and reduced resistance to vinblastine, and had no effect on actinomycin D resistance. Login to comment 164 ABCB1 p.Gly341Val Additionally, the mutation of Gly to Val at position 341 resulted in little resistance to colchicine and doxorubicin but retention of resistance to vinblastine and actinomycin D (140). Login to comment 177 ABCB1 p.Gly185Val One of the best-characterized mutations, of Gly to Val at position 185, results in increased resistance to colchicine and etoposide but decreased resistance to actinomycin D, vinblastine, doxorubicin, vincristine, and taxol (52, 63,129,197). Login to comment 180 ABCB1 p.Asn183Ser This mutation made in conjunction with an Asn-to-Ser mutation at position 183 results in recovery of resistance to actinomycin D, vinblastine, and doxorubicin and retention of resistance to colchicine (63). Login to comment 1087 ABCB1 p.Gly185Val Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells. Login to comment 1088 ABCB1 p.Gly185Val Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells. Login to comment