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PMID: 8825488
Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I
Genetic analysis of the multidrug transporter.
Annu Rev Genet. 1995;29:607-49.,
[PubMed]
Sentences
No.
Mutations
Sentence
Comment
163
ABCB1 p.Val338Ala
X
ABCB1 p.Val338Ala 8825488:163:2
status:
NEW
view ABCB1 p.Val338Ala details
A
Val-to-Ala mutation at position 338
resulted in increased resistance to colchicine and doxorubicin and reduced resistance to vinblastine, and had no effect on actinomycin D resistance.
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164
ABCB1 p.Gly341Val
X
ABCB1 p.Gly341Val 8825488:164:30
status:
NEW
view ABCB1 p.Gly341Val details
Additionally, the mutation of
Gly to Val at position 341
resulted in little resistance to colchicine and doxorubicin but retention of resistance to vinblastine and actinomycin D (140).
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177
ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 8825488:177:44
status:
NEW
view ABCB1 p.Gly185Val details
One of the best-characterized mutations, of
Gly to Val at position 185
, results in increased resistance to colchicine and etoposide but decreased resistance to actinomycin D, vinblastine, doxorubicin, vincristine, and taxol (52, 63,129,197).
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180
ABCB1 p.Asn183Ser
X
ABCB1 p.Asn183Ser 8825488:180:42
status:
NEW
view ABCB1 p.Asn183Ser details
This mutation made in conjunction with an
Asn-to-Ser mutation at position 183
results in recovery of resistance to actinomycin D, vinblastine, and doxorubicin and retention of resistance to colchicine (63).
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1087
ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 8825488:1087:12
status:
NEW
view ABCB1 p.Gly185Val details
Mutation of
glycine 185 to valine
alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells.
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1088
ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 8825488:1088:12
status:
NEW
view ABCB1 p.Gly185Val details
Mutation of
glycine 185 to valine
alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells.
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