PMID: 7947814

Loo TW, Clarke DM
Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein.
Biochemistry. 1994 Nov 29;33(47):14049-57., [PubMed]
Sentences
No. Mutations Sentence Comment
279 ABCC7 p.Arg347Glu
X
ABCC7 p.Arg347Glu 7947814:279:22
status: NEW
view ABCC7 p.Arg347Glu details
ABCC7 p.Lys335Glu
X
ABCC7 p.Lys335Glu 7947814:279:12
status: NEW
view ABCC7 p.Lys335Glu details
 Mutation of Lys335 or Arg347 to Glu in TM6 altered the permeability and/or conductance ratios for halide ions (Anderson et al., 1991). Login to comment 280 ABCC7 p.Arg347His
X
ABCC7 p.Arg347His 7947814:280:12
status: NEW
view ABCC7 p.Arg347His details
 Mutation of Arg347 to His resulted in the ability of CFTR to eliminate the multiple ion occupancy effects when the pH of the intracellular solution is changed (Tabcharani et al., 1993). Login to comment