PMID: 7731035

Leveille-Webster CR, Arias IM
The biology of the P-glycoproteins.
J Membr Biol. 1995 Jan;143(2):89-102., [PubMed]
Sentences
No. Mutations Sentence Comment
204 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 7731035:204:34
status: NEW
view ABCB1 p.Gly185Val details
 A naturally occurring mutation of glycine to valine at position 185 in transmembrane domain 3 of human MDR1 changed the specificity of the transporter so that colchicine and etoposide resistance were enhanced while resistance to vinblastine, vincristine and actinomycin D was decreased [48, 104, 150]. Login to comment 207 ABCB3 p.Gly338Ala
X
ABCB3 p.Gly338Ala 7731035:207:12
status: NEW
view ABCB3 p.Gly338Ala details
ABCB3 p.Gly338Ala
X
ABCB3 p.Gly338Ala 7731035:207:12
status: NEW
view ABCB3 p.Gly338Ala details
 Mutation of glycine 338 to alanine and alanine 339 to proline in transmembrane domain 6 in hamster p-glycoprotein decreased resistance to several drugs while maintaining normal resistance to actinomycin D [63]. Login to comment