PMID: 7544439

Knowles MR, Hohneker KW, Zhou Z, Olsen JC, Noah TL, Hu PC, Leigh MW, Engelhardt JF, Edwards LJ, Jones KR, et al.
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis.
N Engl J Med. 1995 Sep 28;333(13):823-31., [PubMed]
Sentences
No. Mutations Sentence Comment
51 ABCC7 p.Arg347Pro
X
ABCC7 p.Arg347Pro 7544439:51:91
status: NEW
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ABCC7 p.Arg347Pro
X
ABCC7 p.Arg347Pro 7544439:51:115
status: NEW
view ABCC7 p.Arg347Pro details
ABCC7 p.Asn1303Lys
X
ABCC7 p.Asn1303Lys 7544439:51:36
status: NEW
view ABCC7 p.Asn1303Lys details
 *N1303K indicates a substitution of lysine for asparagine at amino acid position 1303, and R347P a substitution of proline for arginine at position 347. Login to comment 55 ABCC7 p.Arg347Pro
X
ABCC7 p.Arg347Pro 7544439:55:415
status: NEW
view ABCC7 p.Arg347Pro details
ABCC7 p.Arg347Pro
X
ABCC7 p.Arg347Pro 7544439:55:568
status: NEW
view ABCC7 p.Arg347Pro details
ABCC7 p.Asn1303Lys
X
ABCC7 p.Asn1303Lys 7544439:55:220
status: NEW
view ABCC7 p.Asn1303Lys details
 SEX/AGE (YR) GENOTYPE* ADENOVIRAL VECTOR CONCENTRATION (pfu/ml) VOLUME (ml) DOSE (pfu) ESTIMATED MULTIPLICITY OF INFECTION Cohort 1 1 2 3 F/25 F/39 M/44 ⌬F508 /⌬F508 ⌬F508 /⌬F508 ⌬F508/N1303K 107 2 2ϫ107 1 Cohort 2 4 5 6 M/23 F/32 M/21 ⌬F508 /⌬F508 ⌬F508/⌬F508 ⌬F508/Unknown 108 2 2ϫ108 10 Cohort 3 7 8 9 F/24 F/34 F/40 ⌬F508/R347P ⌬F508/⌬F508 ⌬F508/⌬F508 109 2 2ϫ109 100 Cohort 4 10 11 12 F/19 M/19 M/29 ⌬F508/⌬F508 ⌬F508 /R347P ⌬F508/⌬F508 1010 2 2ϫ1010 1000 enoviral vector by paired t-tests. Login to comment