ABCMdb

PMID: 2964367

Eid P, Bandu MT, Uze G, Mogensen KE
Interferon removes its own receptors as it blocks the division of Daudi cells.
Eur J Biochem. 1988 Feb 1;171(3):675-82., [PubMed]

Sentences

No. Mutations Sentence Comment

86 ABCC8 p.Leu1210Arg (A) The neutral cxtract from Daudi cells treated with IFN at 75 pM for 30 min; (B) as in A but with a monoclonal antibody to IFN present; (C)profile for IFN and antibody alone; (D) same as A but with the digitonin at pH 3 (0.1 M acetic acid); (E)same as A but with 1 mM 1,4-dithioerythritolpresent; (F) extract from untreated Daudi cells to which IFN and 1,4-dithioerythritol had been added together; (G) extract from untreated Daudi cells to which IFN has been added alone; (H) extract from untreated mouse cells (L1210R) to which IFN has been added alone approximately linear on log M , of the protein markers. Login to comment 116 ABCC8 p.Leu1210Arg Fig. 2G (Daudi extract) and Fig. 2H (mouse L1210R extract) suggest that scrambling is probably unrelated to receptor binding as the R strain of the mouse lymphoma line L1210 is resistant to IFN and possesses no receptors [20]. Login to comment