PMID: 26579371

Wu CP, V Ambudkar S
The pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapy.
Acta Pharm Sin B. 2014 Apr;4(2):105-11. doi: 10.1016/j.apsb.2013.12.001. Epub 2014 Jan 13., [PubMed]
Sentences
No. Mutations Sentence Comment
72 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 26579371:72:79
status: NEW
view ABCG2 p.Gln141Lys details
 Recently, ABCG2 has been linked to the disease gout, as mutations (for example Q141K) in this transporter result in decreased efflux of urate from kidney epithelial cells54,55 . Login to comment