PMID: 26405223

Cheepala SB, Pitre A, Fukuda Y, Takenaka K, Zhang Y, Wang Y, Frase S, Pestina T, Gartner TK, Jackson C, Schuetz JD
The ABCC4 membrane transporter modulates platelet aggregation.
Blood. 2015 Nov 12;126(20):2307-19. doi: 10.1182/blood-2014-08-595942. Epub 2015 Sep 24., [PubMed]
Sentences
No. Mutations Sentence Comment
274 ABCC4 p.Glu757Lys
X
ABCC4 p.Glu757Lys 26405223:274:70
status: NEW
view ABCC4 p.Glu757Lys details
 For example, a nonsynonymous single nucleotide polymorphism in ABCC4, E757K, has strongly reduced function as a result of impaired membrane localization.8 Because this allele occurs frequently in Japanese (18%) and Asians (5%), antiplatelet drug use should be monitored carefully for untoward side effects. Login to comment