PMID: 26354996

Deng J, Coy D, Zhang W, Sunkara M, Morris AJ, Wang C, Chaiswing L, St Clair D, Vore M, Jungsuwadee P
Elevated glutathione is not sufficient to protect against doxorubicin-induced nuclear damage in heart in multidrug resistance-associated protein 1 (Mrp1/Abcc1) null mice.
J Pharmacol Exp Ther. 2015 Nov;355(2):272-9. doi: 10.1124/jpet.115.225490. Epub 2015 Sep 9., [PubMed]
Sentences
No. Mutations Sentence Comment
26 ABCC1 p.Gly671Val
X
ABCC1 p.Gly671Val 26354996:26:95
status: NEW
view ABCC1 p.Gly671Val details
 Wojnowski et al., (2005) reported that patients with a single nucleotide polymorphism in MRP1, G671V, have an increased risk of DOX-induced cardiotoxicity. Login to comment 27 ABCC1 p.Gly671Val
X
ABCC1 p.Gly671Val 26354996:27:18
status: NEW
view ABCC1 p.Gly671Val details
 We expressed this G671V variant in HEK293 cells and demonstrated that its Vmax for efflux of GS-HNE was decreased 85% relative to wild-type (WT) MRP1.We also showed that Mrp1 is the sole mediator of ATP-dependent transport of GS-HNE in mouse cardiac sarcolemmal vesicles (Jungsuwadee et al., 2012). Login to comment