PMID: 26079370

Malik FA, Meissner A, Semenkov I, Molinski S, Pasyk S, Ahmadi S, Bui HH, Bear CE, Lidington D, Bolz SS
Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity.
PLoS One. 2015 Jun 16;10(6):e0130313. doi: 10.1371/journal.pone.0130313. eCollection 2015., [PubMed]
Sentences
No. Mutations Sentence Comment
60 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 26079370:60:148
status: NEW
view ABCC7 p.Gly551Asp details
 This investigation utilized plasmids encoding mutated CFTR proteins containing either a serine-to-alanine mutation at residue 737 (CFTRS737A ) or a glycine to aspartic acid mutation at residue 551 (CFTRG551D ); siRNA reagents ("On-Target plus" siRNA targeting the human AMPK b1;1 catalytic subunit [PRKAA1; cat# L-005027-00] and control, non-targeting siRNA [cat# D-001810-10-05]) were purchased from Dharmacon, Inc. Login to comment 123 ABCC7 p.Ser737Ala
X
ABCC7 p.Ser737Ala 26079370:123:138
status: NEW
view ABCC7 p.Ser737Ala details
 (F) S1P fails to inhibit iodide efflux in na&#ef;ve BHK cells transiently transfected with a plasmid encoding a mutated CFTR containing a serine-to-alanine substitution at amino acid 737 (CFTRS737A ). Login to comment