PMID: 25741042

Suma S, Naito M, Okada R, Kawai S, Yin G, Morita E, Wakai K, Matsuo H, Hamajima N
ASSOCIATIONS BETWEEN BODY MASS INDEX AND SERUM URIC ACID LEVELS IN A JAPANESE POPULATION WERE SIGNIFICANTLY MODIFIED BY LRP2 rs2544390.
Nagoya J Med Sci. 2014 Aug;76(3-4):333-9., [PubMed]
Sentences
No. Mutations Sentence Comment
17 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 25741042:17:43
status: NEW
view ABCG2 p.Gln141Lys details
ABCG2 p.Gln126*
X
ABCG2 p.Gln126* 25741042:17:20
status: NEW
view ABCG2 p.Gln126* details
 Polymorphisms ABCG2 Q126X (rs72552713) and Q141K (rs2231142) have been shown to influence the risk of hyperuricemia through reduction of the uric acid transportation activity.16-18) Our previous studies have confirmed the associations with these polymorphisms,16,19,20) and we observed an interaction with alcohol consumption on SUA in our investigation of the LRP2 intron 1 polymorphism rs2544390.21) Because obesity is an important factor that determines SUA,6) the present study aimed to investigate the interaction between LRP2 rs2544390 and BMI on SUA levels using the same dataset as our previous work. Login to comment