PMID: 25515134

Miura Y, Imamura CK, Fukunaga K, Katsuyama Y, Suyama K, Okaneya T, Mushiroda T, Ando Y, Takano T, Tanigawara Y
Sunitinib-induced severe toxicities in a Japanese patient with the ABCG2 421 AA genotype.
BMC Cancer. 2014 Dec 16;14:964. doi: 10.1186/1471-2407-14-964., [PubMed]
Sentences
No. Mutations Sentence Comment
85 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 25515134:85:449
status: NEW
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ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 25515134:85:381
status: NEW
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ABCG2 p.Gln126*
X
ABCG2 p.Gln126* 25515134:85:415
status: NEW
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 Another population pharmacokinetics study also identified ethnic background as a significant covariate for the Table 1 Genotypes of seven SNPs in CYP3A5, ABCB1 and ABCG2 Gene SNP Allele Amino acid Genotype CYP3A5 rs776746 6986A > G Splice Site AG ABCB1 rs1128503 1236C > T G412G CT ABCB1 rs2032582 2677G > T/A A893S/T GT ABCB1 rs1045642 3435C > T I1145I CT ABCG2 rs2231137 34G > A V12M GG ABCG2 rs72552713 376G > A Q126X GG ABCG2 rs2231142 421C > A Q141K AA prediction of oral clearance [16]. Login to comment 137 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 25515134:137:188
status: NEW
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 Imai Y, Nakane M, Kage K, Tsukahara S, Ishikawa E, Tsuruo T, Miki Y, Sugimoto Y: C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Login to comment