PMID: 25469257

Sari FM, Yanar HT, Ozhan G
Investigation of the functional single-nucleotide polymorphisms in the transporter and susceptibility to colorectal cancer.
Biomed Rep. 2015 Jan;3(1):105-109. Epub 2014 Nov 11., [PubMed]
Sentences
No. Mutations Sentence Comment
20 ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 25469257:20:51
status: NEW
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ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 25469257:20:61
status: NEW
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 The BCRP 34G>A variant (rs2231137), resulting in a Val12Met (V12M) substitution, results in apical plasma membrane dislocalization of BCRP and generates a protein with a significantly reduced ability to transport several drugs/xenobiotics. Login to comment 21 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 25469257:21:46
status: NEW
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ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 25469257:21:57
status: NEW
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 The BCRP 421C>A variant (rs2231142), causes a Gln141Lys (Q141K) change, and is associated with low levels of BCRP expression (13). Login to comment