PMID: 25451572

Kranz J, Hessel S, Aretz J, Seidel A, Petzinger E, Geyer J, Lampen A
The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.
Chem Biol Interact. 2014 Oct 16;224C:36-41. doi: 10.1016/j.cbi.2014.10.009., [PubMed]
Sentences
No. Mutations Sentence Comment
172 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 25451572:172:58
status: NEW
view ABCG2 p.Gln141Lys details
 One of these SNP, C421A generates an amino acid exchange (Gln141Lys) at the N-terminus of the protein and was shown to decrease the protein expression level and ATPase activity of the ABCG2 transporter [19,27]. Login to comment