PMID: 25281745

Cole SP
Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.
J Biol Chem. 2014 Nov 7;289(45):30880-8. doi: 10.1074/jbc.R114.609248. Epub 2014 Oct 3., [PubMed]
Sentences
No. Mutations Sentence Comment
69 ABCC1 p.Pro1150Ala
X
ABCC1 p.Pro1150Ala 25281745:69:5
status: NEW
view ABCC1 p.Pro1150Ala details
 When Pro1150 is replaced by Ala (or Leu or Val), the mutant protein exhibits substantially increased levels of methotrexate and E217betaG transport, due to a change in Kmapp (39). Login to comment 70 ABCC1 p.Pro1150Ala
X
ABCC1 p.Pro1150Ala 25281745:70:101
status: NEW
view ABCC1 p.Pro1150Ala details
 This increase is substrate-selective, however, because the transport of other OAs (e.g. LTC4) by the P1150A mutant is unchanged. Login to comment