ABCC1 p.Pro1150Ala

Predicted by SNAP2: A: N (57%), C: N (57%), D: D (66%), E: D (66%), F: D (59%), G: D (63%), H: D (63%), I: D (63%), K: D (66%), L: D (59%), M: D (59%), N: D (59%), Q: D (59%), R: D (63%), S: N (57%), T: D (59%), V: D (63%), W: D (71%), Y: D (59%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Koike K, Conseil G, Leslie EM, Deeley RG, Cole SP
Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.
J Biol Chem. 2004 Mar 26;279(13):12325-36. Epub 2004 Jan 13., 2004-03-26 [PMID:14722114]

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[hide] Letourneau IJ, Slot AJ, Deeley RG, Cole SP
Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function.
Drug Metab Dispos. 2007 Aug;35(8):1372-9. Epub 2007 May 9., [PMID:17494643]

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[hide] Letourneau IJ, Nakajima A, Deeley RG, Cole SP
Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.
Biochem Pharmacol. 2008 Apr 15;75(8):1659-69. Epub 2008 Feb 5., 2008-04-15 [PMID:18336795]

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[hide] He SM, Li R, Kanwar JR, Zhou SF
Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1).
Curr Med Chem. 2011;18(3):439-81., [PMID:21143116]

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[hide] Cole SP
Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.
J Biol Chem. 2014 Nov 7;289(45):30880-8. doi: 10.1074/jbc.R114.609248. Epub 2014 Oct 3., [PMID:25281745]

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