ABCMdb

PMID: 25027185

Liu H, Lin J, Zhu X, Li Y, Fan M, Zhang R, Fang D
Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a high-carbohydrate and low-fat diet in healthy youth.
Biol Res. 2014 Mar 26;47:4. doi: 10.1186/0717-6287-47-4., [PubMed]

Sentences

No. Mutations Sentence Comment

1 ABCA1 p.Arg219Lys And the R219K polymorphism at the gene of ATP-binding cassette transporter 1(ABCA1) was reported to be associated with the profiles. Login to comment 3 ABCA1 p.Arg219Lys This study was to evaluate the effects of ABCA1 R219K polymorphism on serum lipid and apolipoprotein (apo) ratios induced by a high-carbohydrate/low-fat (high-CHO) diet. Login to comment 7 ABCA1 p.Arg219Lys ABCA1 R219K was analyzed by a PCR-RFLP method. Login to comment 12 ABCA1 p.Arg219Lys Conclusions: These results suggest that ABCA1 R219K polymorphism is associated differently in males and females with elevated log(TG/HDL-C) and decreased LDL-C/HDL-C induced by the high-CHO diet. Login to comment 30 ABCA1 p.Arg219Lys One of the most common missense polymorphisms in the coding region of the ABCA1 is R219K polymorphism with an allele frequency of the K allele of 46% in the European population [24]. Login to comment 32 ABCA1 p.Arg219Lys It is believed that the K allele of R219K polymorphism alone is an independent protective factor against CVD. Login to comment 33 ABCA1 p.Arg219Lys However, little is known about the interactions between the R219K polymorphism of ABCA1 and the high-CHO diet and their effects on serum lipids and apolipoproteins in health youth. Login to comment 34 ABCA1 p.Arg219Lys In this study, we investigated the effects of R219K polymorphism of ABCA1 on the anthropometric parameters and plasma lipid and apolipoprotein ratios after the high-CHO diet in healthy young Chinese, a population well characterized with diets containing high carbohydrate and low incidence of CVD. Login to comment 36 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Results The frequencies of genotypes and alleles of R219K polymorphism of ABCA1 The fragment contained R219K polymorphism site of ABCA1 was 177 bp. Login to comment 38 ABCA1 p.Arg219Lys The genotype and allele frequencies of R219K polymorphism of ABCA1 in this study population are shown in Table 1. Login to comment 41 ABCA1 p.Arg219Lys The characteristics of the subjects on the 1st day of this study according to R219K genotypes of ABCA1 Due to the small number of the subjects with the KK genotype, the subjects with the RK genotype and the subjects with the KK genotype were combined and defined as the K allele carriers. Login to comment 55 ABCA1 p.Arg219Lys R219K polymorphism is located on the first intracellular region of ABCA1 protein, where glycosylation sites can be found. Login to comment 64 ABCA1 p.Arg219Lys However, the males with the K allele might be more susceptible than the female counterparts to the favorable effect of R219K polymorphism on serum TG (Table 3), which may be induced by the steroids or other sex hormones [28]. Login to comment 70 ABCA1 p.Arg219Lys To our knowledge, this is the first attempt to investigate the effects of the high-CHO diet on serum lipid ratios and apoA-1/apoB-100 in young subjects with different genotypes of R219K polymorphisms of ABCA1 in a Chinese young population well characterized with a diet of higher carbohydrate and lower fat and a lower incidence of CVD. Login to comment 77 ABCA1 p.Arg219Lys Moreover, unchanged levels of these lipids, or even decreased TG and increased HDL-C and LDL-C, Table 1 Frequencies of the genotype and allele of ABCA1 R219K polymorphism Genotype Allele frequency N RR [case (%)] RK [case (%)] KK [case (%)] R allele K allele Total 56 20 (35.7) 22 (39.3) 14 (25.0) 0.55 0.45 Male 27 8 (14.3) 11 (19.6) 8 (14.3) 0.50 0.50 Female 29 12 (21.4) 11 (19.6) 6 (10.7) 0.60 0.40 were reported after the high-CHO diet [34]. Login to comment 89 ABCA1 p.Arg219Lys Once confirmed by bigger population and multi-center trials, the findings could provide a new point of view for personalized dietary intervention for the subjects with different genotypes of the R219K polymorphism of ABCA1 to reduce the risks of CVD, especially in a country with a quarter of the world's population. Login to comment 110 ABCA1 p.Arg219Lys The primers for the amplification of the DNA fragments containing the R219K polymorphism of ABCA1 by polymerase chain reactions (PCR) were designed according to Clee [24]. Login to comment 113 ABCA1 p.Arg219Lys The genotype of R219K polymorphism of ABCA1 was analyzed by XagI enzyme digestion. Login to comment 189 ABCA1 p.Arg219Lys Li YY, Zhang H, Qin XY, Lu XZ, Yang B, Chen ML: ATP-binding cassette transporter A1 R219K polymorphism and coronary artery disease in Chinese population: a meta-analysis of 5,388 participants. Login to comment 192 ABCA1 p.Arg230Cys Aguilar-Salinas CA, Mu&#f1;oz-Hernandez LL, Cobos-Bonilla M, Ram&#ed;rez-M&#e1;rquez MR, Ordo&#f1;ez-Sanchez ML, Mehta R, Medina-Santillan R, Tusie-Luna MT: The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus. Login to comment 207 ABCA1 p.Arg219Lys Evans D, Beil FU: The association of the R219K polymorphism in the ATP-binding cassette transporter 1 (ABCA1) gene with coronary heart disease and hyperlipidaemia. Login to comment 238 ABCA1 p.Arg219Lys Biosci Trends 2011, 5:198-204. doi:10.1186/0717-6287-47-4 Cite this article as: Liu et al.: Effects of R219K polymorphism of ATP-binding cassette transporter 1 gene on serum lipids ratios induced by a high-carbohydrate and low-fat diet in healthy youth. Login to comment