PMID: 24932285

Moriya H, Saito K, Helsby N, Sugino S, Yamakage M, Sawaguchi T, Takasaki M, Kato H, Kurosawa N
Association between the low-dose irinotecan regimen-induced occurrence of grade 4 neutropenia and genetic variants of in patients with gynecological cancers.
Oncol Lett. 2014 Jun;7(6):2035-2040. Epub 2014 Apr 8., [PubMed]
Sentences
No. Mutations Sentence Comment
29 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 24932285:29:25
status: NEW
view ABCG2 p.Gln141Lys details
 In addition, the 421C>A (Q141K) variant of ATPߛbinding cassette subߛfamily G member 2 (ABCG2), which encodes the breast cancer resistance protein (BCRP), a transporter known to target various anticancer drugs, including CPTߛ11, has been reported to reduce the expression of ABCG2 and cause resistance to CPTߛ11 in vitro (20). Login to comment