PMID: 24718721

El Mesallamy HO, Rashed WM, Hamdy NM, Hamdy N
High-dose methotrexate in Egyptian pediatric acute lymphoblastic leukemia: the impact of ABCG2 C421A genetic polymorphism on plasma levels, what is next?
J Cancer Res Clin Oncol. 2014 Aug;140(8):1359-65. doi: 10.1007/s00432-014-1670-y. Epub 2014 Apr 10., [PubMed]
Sentences
No. Mutations Sentence Comment
32 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 24718721:32:89
status: NEW
view ABCG2 p.Gln141Lys details
 Out of more than 80 single-nucleotide polymorphisms (SNPs) in the ABCG2 gene, the C421A (Q141K) nonsynonymous polymorphism located on exon 5 is the most extensively studied SNP. Login to comment 34 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 24718721:34:32
status: NEW
view ABCG2 p.Gln141Lys details
 The allelic frequency of C421A (Q141K) varies between different populations; it is present in approximately 13 % of Middle Eastern people (Zamber et al. 2003). Login to comment 57 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 24718721:57:112
status: NEW
view ABCG2 p.Gln141Lys details
 Briefly, 200 ng of gDNA was amplified using primers flanking the regions of BCRB C421A polymorphism (rs2231142, Gln 141 Lys). Login to comment