PMID: 24469953

de Lima LT, Vivona D, Bueno CT, Hirata RD, Hirata MH, Luchessi AD, de Castro FA, de Lourdes F Chauffaille M, Zanichelli MA, Chiattone CS, Hungria VT, Guerra-Shinohara EM
Reduced ABCG2 and increased SLC22A1 mRNA expression are associated with imatinib response in chronic myeloid leukemia.
Med Oncol. 2014 Mar;31(3):851. doi: 10.1007/s12032-014-0851-5. Epub 2014 Jan 29., [PubMed]
Sentences
No. Mutations Sentence Comment
174 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 24469953:174:34
status: NEW
view ABCG2 p.Gln141Lys details
 Non-synonymous ABCG2c.421C[A SNP (Q141K) was described as responsible for lower levels of protein expression [41], impaired transport [42, 43], and enhanced susceptibility to ubiquitin-mediated proteasomal degradation [44]. Login to comment