ABCMdb

PMID: 24157307

Hou R, Zhu X, Pan X, Guo R, Ma T, Xu X
ATP-binding cassette transporter A1 R219K polymorphism and ischemic stroke risk in the Chinese population: a meta-analysis.
J Neurol Sci. 2014 Jan 15;336(1-2):57-61. doi: 10.1016/j.jns.2013.10.006. Epub 2013 Oct 12., [PubMed]

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0 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ATP-binding cassette transporter A1 R219K polymorphism and ischemic stroke risk in the Chinese population: A meta-analysis Rongyao Hou a,1,2 , Xiaoyan Zhu b,1,2 , Xudong Pan c, Ìe;,2 , Ruiyou Guo a , Teng Ma a , Xiang Xu c a Department of Neurology, The Affiliated Hiser Hospital of Qingdao University, Qingdao, China b Department of Critical Care Medicine, The Affiliated Hiser Hospital of Qingdao University, Qingdao, China c Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China a b s t r a c t a r t i c l e i n f o Article history: Received 16 July 2013 Received in revised form 13 September 2013 Accepted 3 October 2013 Available online 12 October 2013 Keywords: ATP-binding cassette transporter A1 (ABCA1) Gene polymorphism The Chinese population Ischemic stroke Meta analysis R219K Recently, many studies have been focused on the association between the ATP-binding cassette transporter A1 (ABCA1) gene R219K polymorphism and ischemic stroke (IS). Login to comment 4 ABCA1 p.Arg219Lys Odds ratios with 95% confidence intervals were applied to evaluate the strength of the association between ABCA1 gene R219K polymorphism and IS. Login to comment 7 ABCA1 p.Arg219Lys For R219K in IS, there were significant associations with these genetic models, but not with the recessive genetic model. Login to comment 8 ABCA1 p.Arg219Lys Our meta-analysis indicated that the ABCA1 gene R219K polymorphism might be associated with IS and the K allele might be a protective factor in the Chinese population. Login to comment 30 ABCA1 p.Arg219Lys R219K is a common variation in the ABCA1 gene-coding region. Login to comment 38 ABCA1 p.Arg219Lys One study found that the ABCA1 R219K polymorphism cloud modulate the association between HDL-C and age in whites [17]. Login to comment 39 ABCA1 p.Arg219Lys Another study also found that the ABCA1 R219K polymorphism was associated with a higher HDL-C level in Caucasians and Asians [14]. Login to comment 40 ABCA1 p.Arg219Lys Domestically, results of the widely researched studies of ABCA1 R219K gene polymorphism and IS are still debatable. Login to comment 43 ABCA1 p.Arg219Lys To illustrate inconsistencies, we collected the data from the relevant published literature to quantify the ABCA1 R219K polymorphism effect on the risk of IS in the Chinese population. Login to comment 47 ABCA1 p.Arg219Lys The following medical subject heading (MeSH) terms were used: "cerebrovascular accident," "cerebrovascular disease," "stroke," "cerebral infarct," "polymorphism,""ABCA1,""R219K"and "the Chinese population". Login to comment 50 ABCA1 p.Arg219Lys Selection criteria The included studies were all selected according to the following criteria: (1) studies that related the R219K polymorphism to susceptibility to IS; (2) studies restricted to the Chinese population; (3) a clear diagnosis for IS; (4) applied case-control studies and (5) full-text articles. Login to comment 77 ABCA1 p.Arg219Lys Meta-regression testing can explain Records identified through database searching (n = 38) Articles excluded: Obvious irrelevance (n = 12) Articles screened ( n = 26) Articles excluded: Without Chinese population included (n = 3) Without SNP R219K (n = 6) No case-control studies (n = 2) Duplicated publications (n = 2) No genotype frequency (n = 1) Other not according with standards of research (n = 3) Full-text articles assessed for eligibility (n = 9) No full-text articles excluded Studies included in the meta-analysis (n=9) Fig. 1. Login to comment 90 ABCA1 p.Arg219Lys Discussion The association remains controversial between the R219K polymorphism of ABCA1 and IS in many studies, especially in the Chinese population. Therefore, this meta-analysis was very necessary to evaluate the association. Login to comment 94 ABCA1 p.Arg219Lys It showed that the dominant genetic model (OR = 0.92, 95% CI: 0.88-0.96, P = 0.000), the homozygote genetic model (OR = 0.64, 95% CI: 0.44-0.94, P = 0.02), the heterozygote genetic model (OR = 0.81, 95% CI: 0.69-0.95, P = 0.009) and the allelic genetic model (OR = 0.83,95% CI:0.69-0.99, P = 0.036) indicated a significant association between R219K polymorphism and IS. Login to comment 102 ABCA1 p.Arg219Lys Results of the current meta-analysis indicated the R219K polymorphism of ABCA1 gene might be associated with IS and that the K allele might be a protective factor for IS in the Chinese populations. Login to comment 107 ABCA1 p.Arg219Lys Studies on the polymorphism of R219K have focused on the association between AS and lipid metabolism. Login to comment 108 ABCA1 p.Arg219Lys Many of those studies focused on the association about R219K gene polymorphism in AS, coronary heart disease (CHD) and IS [14,15,24]. Login to comment 109 ABCA1 p.Arg219Lys The R219K gene polymorphism correlated with increasing HDL-C, alleviating atherosclerosis and decreasing CHD risk, and described the protective effect against AS and CHD [31,32]. Login to comment 111 ABCA1 p.Arg219Lys Other studies also showed that R219K polymorphism of the ABCA1 gene had a protective effect against IS [18,24]. Login to comment 115 ABCA1 p.Arg219Lys Another study didn't support the ABCA1 R219K polymorphism played a major role among the risk factors of IS [35]. Login to comment 117 ABCA1 p.Arg219Lys In our meta-analysis, the ABCA1 R219K polymorphism might be associated with IS and the K allele maybe a protective factor against IS in the Chinese population. Login to comment 119 ABCA1 p.Arg219Lys Table 2 Summary of meta-analysis of association of ABCA1 R219K polymorphism and IS risk. Login to comment 131 ABCA1 p.Arg219Lys [25] 2012 Ningxia Chinese (Hui) Age, sex, ethnicity PCR-RFLP 105/257 30 63 12 63 125 69 0.669 The reasons for the ABCA1 R219K polymorphism reducing the risk of IS might be the reduction in the incidence of AS. Login to comment 133 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys The studies of R219K gene polymorphism associated with CHD also found that the R219K polymorphism and CHD were closely related, and that the K allele might be a genetic protective factor [31,32]. Login to comment 134 ABCA1 p.Arg219Lys The R219K polymorphism was significantly associated with HDL-C metabolism and CHD risk [36]. Login to comment 136 ABCA1 p.Arg219Lys R219K polymorphism of the ABCA1 gene is associated with susceptibility to IS. Login to comment 137 ABCA1 p.Arg219Lys The above literature was not consistent regarding the risk of the ABCA1 gene R219K polymorphism in the development of IS. Login to comment 154 ABCA1 p.Arg219Lys In conclusion, our meta-analysis indicated that the ABCA1 gene R219K polymorphism might be associated with IS and that the K allele might be a protective factor for IS in the Chinese population. Login to comment 156 ABCA1 p.Arg219Lys In the future, more well-designed research is needed to evaluate the association between the ABCA1 R219K polymorphism and IS. Login to comment