PMID: 23967177

Bhullar J, Natarajan K, Shukla S, Mathias TJ, Sadowska M, Ambudkar SV, Baer MR
The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions.
PLoS One. 2013 Aug 14;8(8):e71266. doi: 10.1371/journal.pone.0071266. eCollection 2013., [PubMed]
Sentences
No. Mutations Sentence Comment
159 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23967177:159:135
status: NEW
view ABCG2 p.Gln141Lys details
 ABCG2 has been found to be a urate efflux transporter, with increased incidence of both hyperuricemia and gout in association with the Q141K ABCG2 single nucleoside polymorphism, which results in decreased urate transport [69]. Login to comment