ABCMdb

PMID: 23935829

Xie Y, Wang M, Zhang Y, Zhang S, Tan A, Gao Y, Liang Z, Shi D, Huang Z, Zhang H, Yang X, Lu Z, Wu C, Liao M, Sun Y, Qin X, Hu Y, Li L, Peng T, Li Z, Yang X, Mo Z
Serum uric acid and non-alcoholic fatty liver disease in non-diabetic Chinese men.
PLoS One. 2013 Jul 23;8(7):e67152. doi: 10.1371/journal.pone.0067152. Print 2013., [PubMed]

Sentences

No. Mutations Sentence Comment

5 ABCG2 p.Gln141Lys A stepwise multivariate linear regression analysis (R2 = 0.238, P,0.001) retained age, waist circumference, serum creatinine, triglycerides, the Q141K variant in ABCG2 (rs2231142) and NAFLD as significant predictors of SUA levels (all P,0.001). Login to comment 88 ABCG2 p.Gln141Lys Among all subjects, a final constructed model using a stepwise method (probability to enter #0.05; to remove $0.10), found age (b = 20.11, 95% CI 20.16 to 20.06), WC (b = 0.17, 95% CI 0.11-0.23), NAFLD (b = 0.15, 95% CI 0.09-0.21), log-transformed serum creatinine (b = 0.29, 95% CI, 0.24-0.34) and triglycerides (b = 0.11, 95% CI 0.05-0.16), as well as the Q141K variant in ABCG2 gene (b = 0.12, 95% CI 0.07-0.17) as significant predictors (all P,0.001) of the logarithm of SUA levels (R2 = 0.238, P,0.001). Login to comment 112 ABCG2 p.Gln141Lys Our present result also suggested that the Q141K variant in ABCG2, leads to variable degree of SUA concentration in men, in conceptual agreement with the ABCG2`s function of altering uric acid transport in kidney proximal tubule cell and excretion in liver via the biliary system [37]. Login to comment 137 ABCG2 p.Gln141Lys SUA are interrelated with age, waist circumference, NAFLD, creatinine, triglycerides, and the Q141K variant in ABCG2 in non-diabetic Chinese men. Login to comment