ABCMdb

PMID: 23892057

Gojanovich GS, Ross P, Holmer SG, Holmes JC, Hess PR
Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris).
Dev Comp Immunol. 2013 Dec;41(4):578-86. doi: 10.1016/j.dci.2013.07.011. Epub 2013 Jul 25., [PubMed]

Sentences

No. Mutations Sentence Comment

179 ABCB3 p.Arg380Gln As seen in Fig. 3, dogs share M218 and A374 with humans, and have an R380Q substitution, identical to rat 2a. Login to comment 188 ABCB2 p.Pro749Thr ABCB3 p.Leu180Pro Five polymorphisms, S125C, L180P, A353S and P749T/L, differentiate the five canine TAP1 alleles (Figs. Login to comment 189 ABCB2 p.Val518Ile Conversely, none of the human TAP1 polymorphic sites (V80G, L131P, I333V, A370V, V458L, V518I, D637G and R648Q) were observed to vary in the deduced sequences from our dogs. Login to comment 190 ABCB2 p.Val518Ile Conversely, none of the human TAP1 polymorphic sites (V80G, L131P, I333V, A370V, V458L, V518I, D637G and R648Q) were observed to vary in the deduced sequences from our dogs. Login to comment 197 ABCB3 p.Arg651Cys ABCB3 p.Val379Ile ABCB3 p.Ala565Thr ABCB3 p.Arg373Cys ABCB2 p.Gln665Ala However, there was no overlap between canine (G127R, R373C, I425T and R695H) and human (V379I, A565T, R651C and Q665A) polymorphisms (http://hla.alleles.org/data/txt/tap2_prot.txt). Login to comment 198 ABCB3 p.Arg651Cys ABCB3 p.Val379Ile ABCB3 p.Ala565Thr ABCB3 p.Arg373Cys ABCB2 p.Gln665Ala However, there was no overlap between canine (G127R, R373C, I425T and R695H) and human (V379I, A565T, R651C and Q665A) polymorphisms (http://hla.alleles.org/data/txt/tap2_prot.txt). Login to comment