PMID: 23892057

Gojanovich GS, Ross P, Holmer SG, Holmes JC, Hess PR
Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris).
Dev Comp Immunol. 2013 Dec;41(4):578-86. doi: 10.1016/j.dci.2013.07.011. Epub 2013 Jul 25., [PubMed]
Sentences
No. Mutations Sentence Comment
179 ABCB3 p.Arg380Gln
X
ABCB3 p.Arg380Gln 23892057:179:69
status: NEW
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As seen in Fig. 3, dogs share M218 and A374 with humans, and have an R380Q substitution, identical to rat 2a. Login to comment
188 ABCB2 p.Pro749Thr
X
ABCB2 p.Pro749Thr 23892057:188:44
status: NEW
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ABCB3 p.Leu180Pro
X
ABCB3 p.Leu180Pro 23892057:188:27
status: NEW
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Five polymorphisms, S125C, L180P, A353S and P749T/L, differentiate the five canine TAP1 alleles (Figs. Login to comment
189 ABCB2 p.Val518Ile
X
ABCB2 p.Val518Ile 23892057:189:88
status: NEW
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Conversely, none of the human TAP1 polymorphic sites (V80G, L131P, I333V, A370V, V458L, V518I, D637G and R648Q) were observed to vary in the deduced sequences from our dogs. Login to comment
190 ABCB2 p.Val518Ile
X
ABCB2 p.Val518Ile 23892057:190:88
status: NEW
view ABCB2 p.Val518Ile details
Conversely, none of the human TAP1 polymorphic sites (V80G, L131P, I333V, A370V, V458L, V518I, D637G and R648Q) were observed to vary in the deduced sequences from our dogs. Login to comment
197 ABCB3 p.Arg651Cys
X
ABCB3 p.Arg651Cys 23892057:197:102
status: NEW
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ABCB3 p.Val379Ile
X
ABCB3 p.Val379Ile 23892057:197:88
status: NEW
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ABCB3 p.Ala565Thr
X
ABCB3 p.Ala565Thr 23892057:197:95
status: NEW
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ABCB3 p.Arg373Cys
X
ABCB3 p.Arg373Cys 23892057:197:53
status: NEW
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ABCB2 p.Gln665Ala
X
ABCB2 p.Gln665Ala 23892057:197:112
status: NEW
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However, there was no overlap between canine (G127R, R373C, I425T and R695H) and human (V379I, A565T, R651C and Q665A) polymorphisms (http://hla.alleles.org/data/txt/tap2_prot.txt). Login to comment
198 ABCB3 p.Arg651Cys
X
ABCB3 p.Arg651Cys 23892057:198:102
status: NEW
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ABCB3 p.Val379Ile
X
ABCB3 p.Val379Ile 23892057:198:88
status: NEW
view ABCB3 p.Val379Ile details
ABCB3 p.Ala565Thr
X
ABCB3 p.Ala565Thr 23892057:198:95
status: NEW
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ABCB3 p.Arg373Cys
X
ABCB3 p.Arg373Cys 23892057:198:53
status: NEW
view ABCB3 p.Arg373Cys details
ABCB2 p.Gln665Ala
X
ABCB2 p.Gln665Ala 23892057:198:112
status: NEW
view ABCB2 p.Gln665Ala details
However, there was no overlap between canine (G127R, R373C, I425T and R695H) and human (V379I, A565T, R651C and Q665A) polymorphisms (http://hla.alleles.org/data/txt/tap2_prot.txt). Login to comment