ABCB2 p.Pro749Thr
| Predicted by SNAP2: | A: N (93%), C: N (87%), D: N (78%), E: N (82%), F: N (93%), G: N (87%), H: N (87%), I: N (87%), K: N (93%), L: N (93%), M: N (78%), N: N (87%), Q: N (97%), R: N (93%), S: N (93%), T: N (93%), V: N (93%), W: N (72%), Y: N (93%), |
| Predicted by PROVEAN: | A: N, C: N, D: N, E: N, F: D, G: N, H: D, I: N, K: N, L: N, M: N, N: N, Q: N, R: N, S: N, T: N, V: N, W: D, Y: D, |
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[hide] Characterization and allelic variation of the tran... Dev Comp Immunol. 2013 Dec;41(4):578-86. doi: 10.1016/j.dci.2013.07.011. Epub 2013 Jul 25. Gojanovich GS, Ross P, Holmer SG, Holmes JC, Hess PR
Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris).
Dev Comp Immunol. 2013 Dec;41(4):578-86. doi: 10.1016/j.dci.2013.07.011. Epub 2013 Jul 25., [PMID:23892057]
Abstract [show]
The function of the transporters associated with antigen processing (TAP) complex is to shuttle antigenic peptides from the cytosol to the endoplasmic reticulum to load MHC class I molecules for CD8(+) T-cell immunosurveillance. Here we report the promoter and coding regions of the canine TAP1 and TAP2 genes, which encode the homologous subunits forming the TAP heterodimer. By sampling genetically divergent breeds, polymorphisms in both genes were identified, although there were few amino acid differences between alleles. Splice variants were also found. When aligned to TAP genes of other species, functional regions appeared conserved, and upon phylogenetic analysis, canine sequences segregated appropriately with their orthologs. Transfer of the canine TAP2 gene into a murine TAP2-defective cell line rescued surface MHC class I expression, confirming exporter function. This data should prove useful in investigating the association of specific TAP defects or alleles with immunity to intracellular pathogens and cancer in dogs.
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No. Sentence Comment
188 Five polymorphisms, S125C, L180P, A353S and P749T/L, differentiate the five canine TAP1 alleles (Figs.
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ABCB2 p.Pro749Thr 23892057:188:44
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