PMID: 23741405

Dickens D, Yusof SR, Abbott NJ, Weksler B, Romero IA, Couraud PO, Alfirevic A, Pirmohamed M, Owen A
A multi-system approach assessing the interaction of anticonvulsants with P-gp.
PLoS One. 2013 May 31;8(5):e64854. doi: 10.1371/journal.pone.0064854. Print 2013., [PubMed]
Sentences
No. Mutations Sentence Comment
60 ABCB1 p.Gly534Asp
X
ABCB1 p.Gly534Asp 23741405:60:81
status: NEW
view ABCB1 p.Gly534Asp details
 The ATPase deficient mutant encodes for a transporter with an amino acid change (G534D) that has previously been ectopically expressed and shown to be expressed at equivalent levels as the wild type protein and with normal membrane insertion but has a complete loss of drug-stimulated ATPase activity [31]. Login to comment