PMID: 23635651

Tiwari AK, Zhang R, Gallo JM
Overlapping functions of ABC transporters in topotecan disposition as determined in gene knockout mouse models.
Mol Cancer Ther. 2013 Jul;12(7):1343-55. doi: 10.1158/1535-7163.MCT-13-0100. Epub 2013 May 1., [PubMed]
Sentences
No. Mutations Sentence Comment
232 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23635651:232:120
status: NEW
view ABCG2 p.Gln141Lys details
 With respect to the latter, a pilot study indicated that the presence of single-nucleotide polymorphisms (SNP) in ABCG2 Q141K (ABCG2 421C>A) in a cohort of patients with cancer significantly altered topotecan bioavailability and increased plasma AUC by 1.35-fold (34). Login to comment