PMID: 23616064

Gervasoni C, Cattaneo D, Falvella FS, Vitiello P, Cheli S, Milazzo L, Clementi E, Riva A
Levofloxacin-induced seizures in a patient without predisposing risk factors: the impact of pharmacogenetics.
Eur J Clin Pharmacol. 2013 Aug;69(8):1611-3. doi: 10.1007/s00228-013-1515-7. Epub 2013 Apr 25., [PubMed]
Sentences
No. Mutations Sentence Comment
43 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23616064:43:492
status: NEW
view ABCG2 p.Gln141Lys details
 This drug can readily cross the BBB [3], Table 1 Genotyping analyses performed in our case Protein Gene Variant Database SNP ID AA substitution MAFa Case genotypeb Functional effect of the variant P-glycoprotein 1 ABCB1 c.1236C>T rs1128503 T=0.451 CT Controversial results P-glycoprotein 1 ABCB1 c.2677G>T rs2032582 Ala893Ser T=0.469 GT Altered P-gp activity and expression P-glycoprotein 1 ABCB1 c.3435T>C rs1045642 C=0.429 TC Decreased mRNA and protein levels BCRP ABCG2 c.421C>A rs2231142 Gln141Lys A=0.111 CA Decreased protein levels OATP1A2 SLCO1A2 c.38T>C rs10841795 Ile13Thr C=0.159 TT Increased protein function OATP1A2 SLCO1A2 c.516A>C rs11568563 Glu172Asp C=0.083 AA Decreased protein function SNP, Single nucleotide polymorphism a Minor allele frequency in the CEU population of the International HapMap Project b All genotypes of our case were determined by Real Time PCR, using the TaqMan&#ae; SNP Genotyping Assays (Applied Biosystems, Foster City, CA) or SimpleProbe Assays (Roche, Italy) Eur J Clin Pharmacol (2013) 69:1611-1613 and thus its effect in the CNS can be rapidly observed. Login to comment