PMID: 23230133

Otero JA, Real R, de la Fuente A, Prieto JG, Marques M, Alvarez AI, Merino G
The bovine ATP-binding cassette transporter ABCG2 Tyr581Ser single-nucleotide polymorphism increases milk secretion of the fluoroquinolone danofloxacin.
Drug Metab Dispos. 2013 Mar;41(3):546-9. doi: 10.1124/dmd.112.049056. Epub 2012 Dec 10., [PubMed]
Sentences
No. Mutations Sentence Comment
16 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23230133:16:95
status: NEW
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ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23230133:16:106
status: NEW
view ABCG2 p.Gln141Lys details
 Several single-nucleotide polymorphisms (SNPs) have been studied in human ABCG2, and of these, Gln141Lys (Q141K) is one of the most important, causing impaired urate transport which may contribute to gout (Woodward et al., 2009). Login to comment 25 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23230133:25:178
status: NEW
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ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23230133:25:185
status: NEW
view ABCG2 p.Gln141Lys details
 ABBREVIATIONS: ABC, ATP-binding cassette; ABCG2, adenosine triphosphate-binding cassette transporter G2; AUC, area under the curve; HPLC, high-performance liquid chromatography; Q141K, Gln141Lys; SNP, single-nucleotide polymorphism; Y581S, Tyr581Ser. Login to comment 73 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23230133:73:11
status: NEW
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 Even human Q141K SNP does not affect the plasma disposition of all ABCG2 substrates (Kim et al., 2007; Adkison et al., 2008; Keskitalo et al., 2009). Login to comment