PMID: 23117072

Seong SJ, Lim M, Sohn SK, Moon JH, Oh SJ, Kim BS, Ryoo HM, Chung JS, Joo YD, Bang SM, Jung CW, Kim DH, Park SY, Yoon SS, Kim I, Lee HG, Won JH, Min YH, Cheong JW, Park JS, Eom KS, Hyun MS, Kim MK, Kim H, Park MR, Park J, Kim CS, Kim HJ, Kim YK, Park EK, Zang DY, Jo DY, Lee HW, Yoon YR
Influence of enzyme and transporter polymorphisms on trough imatinib concentration and clinical response in chronic myeloid leukemia patients.
Ann Oncol. 2013 Mar;24(3):756-60. doi: 10.1093/annonc/mds532. Epub 2012 Oct 31., [PubMed]
Sentences
No. Mutations Sentence Comment
66 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23117072:66:128
status: NEW
view ABCG2 p.Gln141Lys details
 discussion ABCG2 421C>A in exon 5 is a non-synonymous SNP, where a glutamine is substituted with a lysine residue at codon 141 (Q141K). Login to comment 70 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23117072:70:82
status: NEW
view ABCG2 p.Gln141Lys details
 It has been reported that human embryonic kidney 293 cells transfected with ABCG2 Q141K showed a higher imatinib accumulation compared with wild-type ABCG2 in vitro [14]. Login to comment