PMID: 23041352

Estudante M, Morais JG, Soveral G, Benet LZ
Intestinal drug transporters: an overview.
Adv Drug Deliv Rev. 2013 Oct;65(10):1340-56. doi: 10.1016/j.addr.2012.09.042. Epub 2012 Oct 4., [PubMed]
Sentences
No. Mutations Sentence Comment
1150 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 23041352:1150:87
status: NEW
view ABCG2 p.Gln141Lys details
 Recent studies have demonstrated that individuals with reduced BCRP expression levels (Q141K variant) are at increased risk for gefitinib-induced diarrhea and altered pharmacokinetics of 9-aminocamptothecin, diflomotecan, irinotecan, rosuvastatin, sulfasalazine and topotecan [1]. Login to comment