ABCMdb

PMID: 22668585

Kolovou V, Marvaki A, Karakosta A, Vasilopoulos G, Kalogiani A, Mavrogeni S, Degiannis D, Marvaki C, Kolovou G
Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses.
Lipids Health Dis. 2012 Jul 9;11:62., [PubMed]

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No. Mutations Sentence Comment

2 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M) in the position 106626574 according to gender and lipid profile of Greek nurses. Login to comment 6 ABCA1 p.Arg219Lys However, only R219K genotype distribution bared borderline statistical significance (p = 0.08) between the two studied groups. Login to comment 7 ABCA1 p.Arg219Lys Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender. Login to comment 18 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys ABCA1 protein is expressed in liver, macrophages, intestines, lungs etc. Several ABCA1 gene polymorphisms were identified such as rs2230806 (R219K) in the chromosomal position 107620867, rs2230808 (R1587K) in the chromosomal position 106602625 and rs4149313 (I883M) in the chromosomal position 106626574]. Login to comment 19 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys Several ABCA1 gene polymorphisms were identified such as rs2230806 (R219K) in the chromosomal position 107620867, rs2230808 (R1587K) in the chromosomal position 106602625 and rs4149313 (I883M) in the chromosomal position 106626574]. Login to comment 31 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys DNA analysis and determination of blood lipids The ABCA1 gene polymorphisms (R219K, R1587K and I883M) were detected using polymerase chain reaction (PCR) and restricted fragment length polymorphism analysis (RFLP`s). Login to comment 33 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys The oligonucleotide primers used for R219K and R1587K polymorphisms were described by Saleheen D et al. [7] and Tupitsina TV et al. [8] respectively. The oligonucleotide primers used for I883M polymorphism were 5`-GAGAAGAGCCACCCTGGTTCCAACCAGAAGAGGAT-3` and 5`- AGAAAGGCAG- GAGACATCGCTT -3 as described by Clee SM et al. [9]. Login to comment 34 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys DNA analysis and determination of blood lipids The ABCA1 gene polymorphisms (R219K, R1587K and I883M) were detected using polymerase chain reaction (PCR) and restricted fragment length polymorphism analysis (RFLP`s). Login to comment 36 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys The oligonucleotide primers used for R219K and R1587K polymorphisms were described by Saleheen D et al. [7] and Tupitsina TV et al. [8] respectively. The oligonucleotide primers used for I883M polymorphism were 5`-GAGAAGAGCCACCCTGGTT- CCAACCAGAAGAGGAT-3` and 5`- AGAAAGGCAG- GAGACATCGCTT -3 as described by Clee SM et al. [9]. Login to comment 39 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys The Kruskal - Wallis H statistic was employed in order to detect differences in lipid levels according to three different polymorphisms of ABCA1 gene (R219K, R1587K and I883M). Login to comment 42 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys The Kruskal - Wallis H statistic was employed in order to detect differences in lipid levels according to three different polymorphisms of ABCA1 gene (R219K, R1587K and I883M). Login to comment 50 ABCA1 p.Ile883Met Figure 1 Gel electrophoresis of I883M gene polymorphism. Login to comment 51 ABCA1 p.Arg219Lys However, only R219K distribution bared borderline significance between the two groups studied (Table 2). Login to comment 52 ABCA1 p.Arg219Lys A post hoc power calculation was conducted employing the calculated differences in the distribution of R219K polymorphism between men and women. Login to comment 53 ABCA1 p.Ile883Met Figure 1 Gel electrophoresis of I883M gene polymorphism. Login to comment 54 ABCA1 p.Arg219Lys However, only R219K distribution bared borderline significance between the two groups studied (Table 2). Login to comment 55 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys A post hoc power calculation was conducted employing the calculated differences in the distribution of R219K polymorphism between men and women. Login to comment 58 ABCA1 p.Arg219Lys Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender (Table 2). Login to comment 61 ABCA1 p.Ile883Met In the present study, we assessed more subjects, included men and evaluated one more polymorphism, namely rs4149313 (I883M). Login to comment 62 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys R219K polymorphism One of the first study which evaluated the R219K polymorphism and lipid profile in man was published by Clee SM et al. [9]. Login to comment 64 ABCA1 p.Ile883Met In the present study, we assessed more subjects, included men and evaluated one more polymorphism, namely rs4149313 (I883M). Login to comment 65 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys R219K polymorphism One of the first study which evaluated the R219K polymorphism and lipid profile in man was published by Clee SM et al. [9]. Login to comment 67 ABCA1 p.Arg219Lys Since then, many other studies correlated the R219K variant with the lipid profile and risk for CAD in various populations and ethnicities [6,9-16]. Login to comment 70 ABCA1 p.Arg219Lys Since then, many other studies correlated the R219K variant with the lipid profile and risk for CAD in various populations and ethnicities [6,9-16]. Login to comment 73 ABCA1 p.Ile883Met ABCA1 p.Ile883Met ABCA1 p.Ile883Met ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Table 2 Distribution of R219K, R1587K and I883M polymorphisms and allele frequencies according to sex Men(n = 87) Women(n = 360) P R219K RR 39 (17.3%) 186 (82.7%) 0.08* RK 45 (23.8%) 144 (76.2%) KK 3(9.4%) 29 (90.6%) R1587K RR 37 (17.5%) 174 (82.5%) 0.12* RK 45 (23.5%) 146 (76.5%) KK 5 (11.4%) 39 (88.6%) I883M II 64 (20.7%) 245 (79.3%) 0.66* IM 22 (17.2%) 106 (82.8%) MM 1 (12.5%) 7 (87.5 %) Allele frequencies for R219K polymorphism R allele frequency 0.71 0.72 0.85** K allele frequency 0.29 0.28 Allele frequencies for R1587K polymorphism R allele frequency 0.68 0.69 0.85** K allele frequency 0.32 0.31 Allele frequencies for I883M polymorphism I allele frequency 0.86 0.83 0.4** M allele frequency 0.17 0.14 Fisher`s exact test - **Test for equality of proportions. Login to comment 76 ABCA1 p.Ile883Met ABCA1 p.Ile883Met ABCA1 p.Ile883Met ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Table 2 Distribution of R219K, R1587K and I883M polymorphisms and allele frequencies according to sex Men(n = 87) Women(n = 360) P R219K RR 39 (17.3%) 186 (82.7%) 0.08* RK 45 (23.8%) 144 (76.2%) KK 3(9.4%) 29 (90.6%) R1587K RR 37 (17.5%) 174 (82.5%) 0.12* RK 45 (23.5%) 146 (76.5%) KK 5 (11.4%) 39 (88.6%) I883M II 64 (20.7%) 245 (79.3%) 0.66* IM 22 (17.2%) 106 (82.8%) MM 1 (12.5%) 7 (87.5 %) Allele frequencies for R219K polymorphism R allele frequency 0.71 0.72 0.85** K allele frequency 0.29 0.28 Allele frequencies for R1587K polymorphism R allele frequency 0.68 0.69 0.85** K allele frequency 0.32 0.31 Allele frequencies for I883M polymorphism I allele frequency 0.86 0.83 0.4** M allele frequency 0.17 0.14 Fisher`s exact test - **Test for equality of proportions. Login to comment 79 ABCA1 p.Arg219Lys In our study, we do not find any association of the R219K variant with any parameter of the lipid profile. Login to comment 81 ABCA1 p.Arg219Lys Noteworthy to mention is that the R219K distribution bared borderline statistical significance (p = 0.08) between two studied groups. Login to comment 82 ABCA1 p.Arg219Lys In our study, we do not find any association of the R219K variant with any parameter of the lipid profile. Login to comment 84 ABCA1 p.Arg219Lys Noteworthy to mention is that the R219K distribution bared borderline statistical significance (p = 0.08) between two studied groups. Login to comment 89 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys In this study we found according to gender that blood lipid levels did not Table 3 Blood lipid levels according to ABCA1 polymorphisms in all subjects ALL SUBJECTS (n = 447) Genotype Median IQR Pߤ R219K Total cholesterol (mg/dl) RR 199 [160 - 239] 0.74 RK 194 [158 - 241] KK 205 [160-244] Triglycerides (mg/dl) RR 98 [65 - 162] 0.66 RK 98 [63 - 170] KK 95 [69 - 140] HDL cholesterol (mg/dl) RR 66 [51 - 80] 0.94 RK 64 [52.5 - 84] KK 63 [50.5 - 85] LDL cholesterol (mg/dl) RR 106 [78 - 131] 0.18 RK 104 [71.5 - 131] KK 118 [92-147] Apo A1 (mg/dl) RR 139 [108 - 180] 0.09 RK 152 [106-187] KK 164 [115-202] R1587K Total cholesterol (mg/dl) RR 190 [145 - 238] 0.08 RK 203 [170 - 241] KK 199 [158 - 222] Triglycerides (mg/dl) RR 95 [60 - 167] 0.35 RK 103 [68 - 168] KK 85 [69-150] HDL cholesterol (mg/dl) RR 65 [51 - 81] 0.73 RK 65 [53 - 83] KK 62 [47 - 85] LDL cholesterol (mg/dl) RR 100 [66 - 122] 0.0025 RK 114 [84 -139] KK 88 [87 - 89] Apo A1 (mg/dl) RR 145 [104 - 185] 0.78 RK 148 [109 - 180] KK 147 [107 - 194] I883M Total cholesterol (mg/dl) II 198 [155 - 240] 0.74 IM 198 [164 - 238] MM 197 [175 - 253] Triglycerides (mg/dl) II 99 [65 - 163] 0.49 IM 91 [62 - 171] MM 170 [78 - 233] HDL cholesterol (mg/dl) II 65 [51 - 82] 0.83 IM 64 [52 - 82] MM 68 [55 - 95] LDL cholesterol (mg/dl) II 105 [74 - 130] 0.52 IM 108 [81 - 133] MM 117 [64 - 132] Table 3 Blood lipid levels according to ABCA1 polymorphisms in all subjects (Continued) Apo A1 (mg/dl) II 143 [104 - 182] 0.62 IM 148 [109 - 184] MM 153 [111 - 200] HDL: high density lipoprotein, LDL: low density lipoprotein, Apo A1: apolipoprotein A1. Login to comment 92 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys In this study we found according to gender that blood lipid levels did not Table 3 Blood lipid levels according to ABCA1 polymorphisms in all subjects ALL SUBJECTS (n = 447) Genotype Median IQR P† R219K Total cholesterol (mg/dl) RR 199 [160 - 239] 0.74 RK 194 [158 - 241] KK 205 [160-244] Triglycerides (mg/dl) RR 98 [65 - 162] 0.66 RK 98 [63 - 170] KK 95 [69 - 140] HDL cholesterol (mg/dl) RR 66 [51 - 80] 0.94 RK 64 [52.5 - 84] KK 63 [50.5 - 85] LDL cholesterol (mg/dl) RR 106 [78 - 131] 0.18 RK 104 [71.5 - 131] KK 118 [92-147] Apo A1 (mg/dl) RR 139 [108 - 180] 0.09 RK 152 [106-187] KK 164 [115-202] R1587K Total cholesterol (mg/dl) RR 190 [145 - 238] 0.08 RK 203 [170 - 241] KK 199 [158 - 222] Triglycerides (mg/dl) RR 95 [60 - 167] 0.35 RK 103 [68 - 168] KK 85 [69-150] HDL cholesterol (mg/dl) RR 65 [51 - 81] 0.73 RK 65 [53 - 83] KK 62 [47 - 85] LDL cholesterol (mg/dl) RR 100 [66 - 122] 0.0025 RK 114 [84 -139] KK 88 [87 - 89] Apo A1 (mg/dl) RR 145 [104 - 185] 0.78 RK 148 [109 - 180] KK 147 [107 - 194] I883M Total cholesterol (mg/dl) II 198 [155 - 240] 0.74 IM 198 [164 - 238] MM 197 [175 - 253] Triglycerides (mg/dl) II 99 [65 - 163] 0.49 IM 91 [62 - 171] MM 170 [78 - 233] HDL cholesterol (mg/dl) II 65 [51 - 82] 0.83 IM 64 [52 - 82] MM 68 [55 - 95] LDL cholesterol (mg/dl) II 105 [74 - 130] 0.52 IM 108 [81 - 133] MM 117 [64 - 132] Table 3 Blood lipid levels according to ABCA1 polymorphisms in all subjects (Continued) Apo A1 (mg/dl) II 143 [104 - 182] 0.62 IM 148 [109 - 184] MM 153 [111 - 200] HDL: high density lipoprotein, LDL: low density lipoprotein, Apo A1: apolipoprotein A1. Login to comment 97 ABCA1 p.Ile883Met ABCA1 p.Ile883Met I883M polymorphism Tan et al. [19] studied the I883M variant in Malays and Chinese population. Login to comment 99 ABCA1 p.Ile883Met However, Clee et al. [9] did not find any difference according to lipid levels and genotypes in carriers of the I883M, although individuals with MM genotype had higher progression in minimum obstruction diameter and cardiac event rate compared with the II genotype individuals. Login to comment 100 ABCA1 p.Ile883Met Hodof;lugil et al. [20] correlated the I883M variant with higher HDL-C concentration in both sexes. Login to comment 101 ABCA1 p.Ile883Met ABCA1 p.Ile883Met ABCA1 p.Ile883Met I883M polymorphism Tan et al. [19] studied the I883M variant in Malays and Chinese population. Login to comment 102 ABCA1 p.Ile883Met Additionally, Mantaring et al. [17] found some differences in allele frequency of I883M gene, which were also present between the highest and lowest HDL-C concentration groups (36% vs 20%; Ptrend = 0.05). Login to comment 103 ABCA1 p.Ile883Met ABCA1 p.Ile883Met However, Clee et al. [9] did not find any difference according to lipid levels and genotypes in carriers of the I883M, although individuals with MM genotype had higher progression in minimum obstruction diameter and cardiac event rate compared with the II genotype individuals. Login to comment 104 ABCA1 p.Ile883Met ABCA1 p.Ile883Met ABCA1 p.Arg219Lys Hodoğlugil et al. [20] correlated the I883M variant with higher HDL-C concentration in both sexes. Login to comment 105 ABCA1 p.Ile883Met Similarly, Jensen et al. [21] among younger women and Porchay-Baldérelli et al. [22] in population with type 2 diabetes mellitus found that the M allele of I883M was associated with higher HDL-C concentration. Login to comment 106 ABCA1 p.Ile883Met ABCA1 p.Ile883Met Additionally, Mantaring et al. [17] found some differences in allele frequency of I883M gene, which were also present between the highest and lowest HDL-C concentration groups (36% vs 20%; Ptrend = 0.05). Login to comment 107 ABCA1 p.Ile883Met ABCA1 p.Ile883Met On the contrary, Kitjaroentham et al. [15] did not find any difference in HDL-C concentrations among I883M genotype polymorphism. Login to comment 108 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys Although, this variant was common in Thai Table 4 Blood lipid levels according to ABCA1 polymorphisms in men MEN (n = 87) Genotype Median IQR P† R219K Total cholesterol (mg/dl) RR 199 [149 - 250] 0.86 RK 205 [164 - 258] KK 222 [122 - 240] Triglycerides (mg/dl) RR 125 [100 - 177] 0.58 RK 142 [97 - 196] KK 134 [50 - 163] HDL cholesterol (mg/dl) RR 61 [49 - 74] 0.28 RK 57 [46 - 81] KK 46 [45 - 48] LDL cholesterol (mg/dl) RR 109 [66 - 146] 0.84 RK 106 [76 - 150] KK 149 [67 - 159] Apo A1 (mg/dl) RR 112 [100 - 135] 0.58 RK 117 [95 - 168] KK 116 [81 - 180] R1587K Total cholesterol (mg/dl) RR 192 [146 - 273] 0.28 RK 206 [166 - 241] KK 122 [110 - 205] Triglycerides (mg/dl) RR 131 [79 - 199] 0.92 RK 131 [100 - 176] KK 153 [108 - 170] HDL cholesterol (mg/dl) RR 60 [51 - 74] 0.41 RK 58 [48 - 76] KK 45 [42 - 48] LDL cholesterol (mg/dl) RR 99 [70 - 150] 0.16 RK 119 [81 - 149] KK 67 [58-106] Apo A1 (mg/dl) RR 114 [94 - 156] 0.79 RK 116 [100 - 149] KK 100 [96 - 116] I883M Total cholesterol (mg/dl) II 201 [148 - 255] 0.27 IM 214 [180 - 241] MM 120 - Triglycerides (mg/dl) II 126 [84-177] 0.18 IM 169 [118 - 250] MM 152 - HDL cholesterol (mg/dl) II 59 [47 - 75] 0.44 IM 57 [48 - 78] MM 41 - LDL cholesterol (mg/dl) II 111 [70-148] 0.39 IM 105 [80 - 149] MM 49 - Table 4 Blood lipid levels according to ABCA1 polymorphisms in men (Continued) Apo A1 (mg/dl) II 110 [94 - 148] 0.14 IM 148 [107 - 169] MM 112 - HDL: high density lipoprotein, LDL: low density lipoprotein, Apo A1: apolipoprotein A1. Login to comment 109 ABCA1 p.Arg219Lys However, there are some data from Delgado-Lista et al. [24] suggesting that the major allele homozygotes for ABCA1 gene polymorphisms i27943 (rs2575875) and R219K (rs2230806) have a lower postprandial response as compared to minor allele carriers. Login to comment 111 ABCA1 p.Ile883Met Similarly, Frikke-Schmidt et al. [14] found that I883M did not affect HDL-C levels but predicted higher risk of CAD. Login to comment 112 ABCA1 p.Ile883Met Also, Sandhofer et al. [23] found that I883M variant showed no effect on plasma lipids or carotid atherosclerosis. Login to comment 114 ABCA1 p.Arg219Lys However, there are some data from Delgado-Lista et al. [24] suggesting that the major allele homozygotes for ABCA1 gene polymorphisms i27943 (rs2575875) and R219K (rs2230806) have a lower postprandial response as compared to minor allele carriers. Login to comment 119 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys Authors` contributions VK participated in the development of hypothesis, drafting of the manuscript and carried out the genetic analysis, AM participated in the molecular Table 5 Blood lipid levels according to ABCA1 polymorphisms in women WOMEN (n = 360) Genotype Median IQR Pߤ R219K Total cholesterol (mg/dl) RR 200 [160 - 238] 0.64 RK 193 [155 - 238] KK 204 [163 - 249] Triglycerides (mg/dl) RR 89 [57 - 152] 0.88 RK 87 [61 - 159] KK 94 [70 - 134] HDL cholesterol (mg/dl) RR 66 [52 - 82] 0.84 RK 65 [55 - 85] KK 66 [55 - 85] LDL cholesterol (mg/dl) RR 105 [79 - 127] 0.18 RK 104 [70 - 126] KK 117 [93 - 141] Apo A1 (mg/dl) RR 145 [111 - 187] 0.16 RK 155 [110 - 194] KK 164 [122 - 204] R1587K Total cholesterol (mg/dl) RR 189 [145 - 231] 0.09 RK 203 [172 - 240] KK 203 [163 - 224] Triglycerides (mg/dl) RR 87 [57 - 146] 0.61 RK 96 [61 - 160] KK 81 [69 - 136] HDL cholesterol (mg/dl) RR 66 [51 - 82] 0.82 RK 67 [55 - 84] KK 64 [52 - 86] LDL cholesterol (mg/dl) RR 100 [66 - 121] 0.0053 RK 112 [85 - 132] KK 106 [83 - 133] Apo A1 (mg/dl) RR 152 [109 - 189] 0.59 RK 155 [114 - 188] KK 153 [116 - 194] I883M Total cholesterol (mg/dl) II 198 [156 - 237] 0.54 IM 196 [160 - 238] MM 214 [181 - 273] Triglycerides (mg/dl) II 90 [61-155] 0.45 IM 86 [58 - 148] MM 188 [73 - 274] HDL cholesterol (mg/dl) II 66 [52-82.5] 0.61 IM 66 [53 - 83] MM 73 [60 - 111] LDL cholesterol (mg/dl) II 104 [74 - 125] 0.34 IM 109 [83 - 132] MM 124 [66 - 134] Table 5 Blood lipid levels according to ABCA1 polymorphisms in women (Continued) Apo A1 (mg/dl) II 154 [111-189] 0.86 IM 149 [110 - 188] MM 166 [110 - 226] HDL: high density lipoprotein, LDL: low density lipoprotein, Apo A1: apolipoprotein A1. Login to comment 124 ABCA1 p.Ile883Met ABCA1 p.Arg219Lys Authors` contributions VK participated in the development of hypothesis, drafting of the manuscript and carried out the genetic analysis, AM participated in the molecular Table 5 Blood lipid levels according to ABCA1 polymorphisms in women WOMEN (n = 360) Genotype Median IQR P† R219K Total cholesterol (mg/dl) RR 200 [160 - 238] 0.64 RK 193 [155 - 238] KK 204 [163 - 249] Triglycerides (mg/dl) RR 89 [57 - 152] 0.88 RK 87 [61 - 159] KK 94 [70 - 134] HDL cholesterol (mg/dl) RR 66 [52 - 82] 0.84 RK 65 [55 - 85] KK 66 [55 - 85] LDL cholesterol (mg/dl) RR 105 [79 - 127] 0.18 RK 104 [70 - 126] KK 117 [93 - 141] Apo A1 (mg/dl) RR 145 [111 - 187] 0.16 RK 155 [110 - 194] KK 164 [122 - 204] R1587K Total cholesterol (mg/dl) RR 189 [145 - 231] 0.09 RK 203 [172 - 240] KK 203 [163 - 224] Triglycerides (mg/dl) RR 87 [57 - 146] 0.61 RK 96 [61 - 160] KK 81 [69 - 136] HDL cholesterol (mg/dl) RR 66 [51 - 82] 0.82 RK 67 [55 - 84] KK 64 [52 - 86] LDL cholesterol (mg/dl) RR 100 [66 - 121] 0.0053 RK 112 [85 - 132] KK 106 [83 - 133] Apo A1 (mg/dl) RR 152 [109 - 189] 0.59 RK 155 [114 - 188] KK 153 [116 - 194] I883M Total cholesterol (mg/dl) II 198 [156 - 237] 0.54 IM 196 [160 - 238] MM 214 [181 - 273] Triglycerides (mg/dl) II 90 [61-155] 0.45 IM 86 [58 - 148] MM 188 [73 - 274] HDL cholesterol (mg/dl) II 66 [52-82.5] 0.61 IM 66 [53 - 83] MM 73 [60 - 111] LDL cholesterol (mg/dl) II 104 [74 - 125] 0.34 IM 109 [83 - 132] MM 124 [66 - 134] Table 5 Blood lipid levels according to ABCA1 polymorphisms in women (Continued) Apo A1 (mg/dl) II 154 [111-189] 0.86 IM 149 [110 - 188] MM 166 [110 - 226] HDL: high density lipoprotein, LDL: low density lipoprotein, Apo A1: apolipoprotein A1. Login to comment 151 ABCA1 p.Arg219Lys Srinivasan SR, Li S, Chen W, Boerwinkle E, Berenson GS: R219K polymorphism of the ABCA1 gene and its modulation of the variations in serum high-density lipoprotein cholesterol and triglycerides related to age and adiposity in white versus black young adults. Login to comment 157 ABCA1 p.Arg219Lys Srinivasan SR, Li S, Chen W, Boerwinkle E, Berenson GS: R219K polymorphism of the ABCA1 gene and its modulation of the variations in serum high-density lipoprotein cholesterol and triglycerides related to age and adiposity in white versus black young adults. Login to comment 158 ABCA1 p.Arg219Lys Zhao SP, Xiao ZJ, Li QZ, Nie S, Tan LM, Jiang B, Wu J: Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids. Login to comment 164 ABCA1 p.Arg219Lys ABCA1 p.Arg219Lys Zhao SP, Xiao ZJ, Li QZ, Nie S, Tan LM, Jiang B, Wu J: Relationship between ATP-binding cassette transporter 1 R219K genetic variation and blood lipids. Login to comment 170 ABCA1 p.Arg219Lys Kitjaroentham A, Hananantachai H, Tungtrongchitr A, Pooudong S, Tungtrongchitr R: R219K polymorphism of ATP binding cassette transporter A1 related with low HDL in overweight/obese Thai males. Login to comment