PMID: 22647192

Wise JG
Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites.
Biochemistry. 2012 Jun 26;51(25):5125-41. Epub 2012 Jun 12., [PubMed]
Sentences
No. Mutations Sentence Comment
333 ABCB1 p.Gly872Arg
X
ABCB1 p.Gly872Arg 22647192:333:377
status: NEW
view ABCB1 p.Gly872Arg details
ABCB1 p.Met986Arg
X
ABCB1 p.Met986Arg 22647192:333:416
status: NEW
view ABCB1 p.Met986Arg details
ABCB1 p.Val982Arg
X
ABCB1 p.Val982Arg 22647192:333:398
status: NEW
view ABCB1 p.Val982Arg details
ABCB1 p.Phe942Arg
X
ABCB1 p.Phe942Arg 22647192:333:384
status: NEW
view ABCB1 p.Phe942Arg details
ABCB1 p.Ala302Arg
X
ABCB1 p.Ala302Arg 22647192:333:356
status: NEW
view ABCB1 p.Ala302Arg details
ABCB1 p.Ser993Arg
X
ABCB1 p.Ser993Arg 22647192:333:405
status: NEW
view ABCB1 p.Ser993Arg details
ABCB1 p.Phe336Arg
X
ABCB1 p.Phe336Arg 22647192:333:363
status: NEW
view ABCB1 p.Phe336Arg details
 A novel arginine mutagenesis approach for rescuing Pgp folding mutants was used by Loo and Clarke to argue that the bulky arginine side chain, when present in the drug binding site, mimicked the rescue of folding of certain mutations by transport substrates that has been observed.81 Alteration of known substrate affinities was taken as evidence that the A302R, F336R, L339R, G872R, F942R, Q946R, V982R, S993R, and M986R mutations were at drug binding locations. Login to comment