PMID: 22414725

Sodani K, Tiwari AK, Singh S, Patel A, Xiao ZJ, Chen JJ, Sun YL, Talele TT, Chen ZS
GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.
Biochem Pharmacol. 2012 Jun 15;83(12):1613-22. Epub 2012 Mar 7., [PubMed]
Sentences
No. Mutations Sentence Comment
135 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 22414725:135:53
status: NEW
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 Therefore, we used both wild-type (R482) and mutant (R482T) forms of ABCG2 in the present study. Login to comment 136 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 22414725:136:53
status: NEW
view ABCG2 p.Arg482Thr details
 Therefore, we used both wild-type (R482) and mutant (R482T) forms of ABCG2 in the present study. Login to comment 264 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 22414725:264:114
status: NEW
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 Our results showed that GW583340 and GW2974 can inhibit the activity of both wild-type (R482) and mutant variant (R482T) of ABCG2. Login to comment 268 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 22414725:268:114
status: NEW
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 Our results showed that GW583340 and GW2974 can inhibit the activity of both wild-type (R482) and mutant variant (R482T) of ABCG2. Login to comment 388 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 22414725:388:35
status: NEW
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 [38] Alqawi O, Bates S, Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Login to comment