PMID: 22330094

Sekine S, Mitsuki K, Ito K, Kugioka S, Horie T
Sustained intrahepatic glutathione depletion causes proteasomal degradation of multidrug resistance-associated protein 2 in rat liver.
Biochim Biophys Acta. 2012 Jun;1822(6):980-7. Epub 2012 Feb 8., [PubMed]
Sentences
No. Mutations Sentence Comment
19 ABCC2 p.Arg768Trp
X
ABCC2 p.Arg768Trp 22330094:19:48
status: NEW
view ABCC2 p.Arg768Trp details
ABCC2 p.Ile1173Phe
X
ABCC2 p.Ile1173Phe 22330094:19:58
status: NEW
view ABCC2 p.Ile1173Phe details
 Certain DJS mutations (e.g., missence mutations R768W and I1173F; deletion mutation R1392, M1393) have been reported to cause defects in canalicular sorting and rapid proteasomal degradation of the hMRP2 protein [2-4]. Login to comment